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procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

Summary

Gene Symbol

Plod3

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

288583

KEGG Gene ID

rno:288583

PubChem

288583

Alliance of Genome Resources

RGD:631339

Annotation

Keyword

Collagen
Dioxygenase
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Iron
Manganese
Membrane
Metal-binding
Multifunctional enzyme
Reference proteome
Secreted
Signal
Vitamin C

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6J056
Q5U367

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
basement membrane assembly	IEA ISO
hydroxylysine biosynthetic process	IEA ISO
protein O-linked glycosylation	IEA ISO
lung morphogenesis	IEA ISO
protein localization	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

collagen metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular modified amino acid metabolic process [inference]

cellular modified amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

hydroxylysine metabolic process [inference]

hydroxylysine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

hydroxylysine biosynthetic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

basement membrane assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

supramolecular fiber organization [inference]

collagen fibril organization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

epithelial cell morphogenesis [inference]

endothelial cell morphogenesis

animal organ morphogenesis [inference]

lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epidermis morphogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

tissue development [inference]

epithelium development [inference]

neural tube development

tube development [inference]

neural tube development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
extracellular space	IEA ISO ISS
Golgi apparatus	ISO
rough endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

Golgi apparatus

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
L-ascorbic acid binding	IEA
procollagen-lysine 5-dioxygenase activity	IBA IEA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

procollagen galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

procollagen galactosyltransferase activity

glucosyltransferase activity [inference]

procollagen glucosyltransferase activity

catalytic activity, acting on a protein [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K13646

Name

lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]

References

Rhea

RHEA:16569

O₂ + 2-oxoglutarate

CO₂ + succinate

Enzyme

1.14.11.4

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 61 in total

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Species	Gene ID	Orthologous MAtrix
Pseudonaja textilis	113449472	PSETE23310
Ornithorhynchus anatinus	100086224	ORNAN31667
Sarcophilus harrisii	100921874	SARHA15246
Callithrix jacchus	100390092	CALJA25351
Cercocebus atys	105593407	CERAT24072
Macaca mulatta	714283	MACMU31302
Macaca nemestrina	105492738	MACNE44031
Papio anubis	101020298	PAPAN30348
Mandrillus leucophaeus	105543347	MANLE31292
Gorilla gorilla gorilla	101151570	GORGO39572

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements