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glutamate ionotropic receptor AMPA type subunit 1
Summary
- Gene Symbol
-
- GRIA1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Cell projection
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Intellectual disability
- Ligand-gated ion channel
- Palmitate
- Phosphoprotein
- Postsynaptic cell membrane
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to arsenic-containing substance | ||
| positive regulation of excitatory postsynaptic potential | ||
| positive regulation of locomotion involved in locomotory behavior | ||
| regulation of ion transmembrane transport | ||
| behavioral response to pain |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| recycling endosome | ||
| external side of plasma membrane | ||
| synaptic vesicle membrane | ||
| neuron spine | ||
| endoplasmic reticulum-Golgi intermediate compartment membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | ||
| glutamate receptor activity | ||
| glutamate-gated calcium ion channel activity | ||
| small GTPase binding |
GO Hierarchy
molecular function
transporter activity [inference]
binding [inference]
molecular transducer activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ligand-gated monoatomic ion channel activity |
| monoatomic ion transport |
| InterPro |
|---|
| Periplasmic binding protein-like I |
| Receptor, ligand binding region |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:670 | amphetamine abuse | |
| DOID:0060001 | withdrawal disorder | |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | |
| DOID:0081235 | autosomal recessive intellectual developmental disorder 76 | |
| DOID:0081292 | traumatic brain injury | |
| DOID:11832 | visual epilepsy | |
| DOID:1289 | neurodegenerative disease | |
| DOID:13413 | hepatic encephalopathy | |
| DOID:1574 | alcohol use disorder | |
| DOID:1824 | status epilepticus |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 14799 | MGI:95808 | MOUSE05917 | ||
| 38742 | FB:FBgn0004619 | |||
| 44484 | FB:FBgn0264000 | |||
| 50592 | RGD:621531 | RATNO00193 | ||
| 175999 | WB:WBGene00001613 | |||
| 176204 | WB:WBGene00001612 | |||
| 403044 | ZFIN:ZDB-GENE-020125-2 | |||
| 443271 | SHEEP16959 | |||
| 471714 | 9598_0:0016f1 | PANTR36649 | ||
| 489168 | CANLF14893 |
