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NADH:ubiquinone oxidoreductase core subunit S2

Summary

Gene Symbol

Ndufs2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

289218

PubChem

289218

Alliance of Genome Resources

RGD:1307109

Annotation

Keyword

4Fe-4S
Acetylation
Methylation
Mitochondrion inner membrane
NAD
Oxidoreductase
Reference proteome
Respiratory chain
Transit peptide
Translocase
Ubiquinone

Proteins

Displaying 1 entry
UniProt	Protein Name
Q641Y2	Complex I-49kD NADH-ubiquinone oxidoreductase 49 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
mitochondrial electron transport, NADH to ubiquinone	ISO
mitochondrial electron transport, NADH to ubiquinone	IMP	30922174
mitochondrial electron transport, NADH to ubiquinone	IBA
response to oxidative stress
biological_process	ND

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, NADH to ubiquinone

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, NADH to ubiquinone

ATP synthesis coupled electron transport [inference]

mitochondrial ATP synthesis coupled electron transport

cellular process [inference]

cell population proliferation [inference]

neural precursor cell proliferation

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, NADH to ubiquinone

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, NADH to ubiquinone

ATP synthesis coupled electron transport [inference]

mitochondrial ATP synthesis coupled electron transport

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

gliogenesis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

NADH dehydrogenase complex assembly [inference]

mitochondrial respiratory chain complex I assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respiratory chain complex I assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

NADH dehydrogenase complex assembly [inference]

mitochondrial respiratory chain complex I assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respiratory chain complex I assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

gliogenesis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to abiotic stimulus [inference]

response to oxygen levels [inference]

cellular response to oxygen levels

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleoplasm
mitochondrion	ISO
mitochondrial inner membrane	ISO
mitochondrial inner membrane	IDA	30922174
respiratory chain complex I	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

NADH dehydrogenase complex [inference]

respiratory chain complex I

respiratory chain complex [inference]

respiratory chain complex I

transmembrane transporter complex [inference]

respiratory chain complex I

catalytic complex [inference]

oxidoreductase complex [inference]

NADH dehydrogenase complex [inference]

respiratory chain complex I

transporter complex [inference]

transmembrane transporter complex [inference]

respiratory chain complex I

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
NADH dehydrogenase activity	ISO
NADH dehydrogenase (ubiquinone) activity	ISS
NADH dehydrogenase (ubiquinone) activity	ISO
NADH dehydrogenase (ubiquinone) activity	IMP	30922174
oxidoreductase activity, acting on NAD(P)H	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity [inference]

NADH dehydrogenase (ubiquinone) activity

oxidoreductase activity, acting on NAD(P)H

NADH dehydrogenase activity

NADH dehydrogenase (quinone) activity [inference]

NADH dehydrogenase (ubiquinone) activity

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [inference]

NAD(P)H dehydrogenase (quinone) activity [inference]

NADH dehydrogenase (quinone) activity [inference]

NADH dehydrogenase (ubiquinone) activity

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

NADH dehydrogenase (ubiquinone) activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding

quinone binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

small molecule sensor activity [inference]

oxygen sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

NADH dehydrogenase

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
X: Mobilome: prophages, transposons

Displaying **all 7** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
NADH dehydrogenase (ubiquinone) activity
iron-sulfur cluster binding
mitochondrial electron transport, NADH to ubiquinone
oxidoreductase activity, acting on NAD(P)H
oxidoreductase activity
quinone binding

Displaying **all 4** entries
InterPro
NAD(P)H-quinone oxidoreductase subunit D/H
NADH-quinone oxidoreductase, subunit D
NADH
[NiFe]-hydrogenase, large subunit

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4720	Xenbase:XB-GENE-975277	HUMAN53171
Mus musculus	226646		MOUSE30168
Xenopus tropicalis	289218	Xenbase:XB-GENE-975277
Bos taurus	327697		BOVIN25527
Canis lupus familiaris	478981		CANLF14410
Danio rerio	553672		DANRE40127
Macaca mulatta	719935		MACMU24245
Pan troglodytes	747334		PANTR22808
Monodelphis domestica	100028959		MONDO11815
Equus caballus	100066089		HORSE35691