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CCC complex scaffolding subunit CCDC22

Summary

Gene Symbol

CCDC22

Organism

Homo sapiens (human)

External Links

NCBI Gene

28952

PubChem

28952

Alliance of Genome Resources

HGNC:28909

Annotation

Keyword

3D-structure
Coiled coil
Cytoskeleton
Disease variant
Endosome
Intellectual disability
Phosphoprotein
Protein transport
Reference proteome
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
O60826

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
intracellular copper ion homeostasis	IMP	25355947
Golgi to plasma membrane transport	IMP	25355947
cytoplasmic sequestering of NF-kappaB
protein transport	IEA
endocytic recycling	IMP	28892079

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endocytic recycling

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport

vesicle-mediated transport to the plasma membrane [inference]

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

endocytic recycling

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

copper ion homeostasis [inference]

intracellular copper ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular copper ion homeostasis

inorganic ion homeostasis [inference]

copper ion homeostasis [inference]

intracellular copper ion homeostasis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endocytic recycling

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to plasma membrane transport

vesicle-mediated transport to the plasma membrane [inference]

intracellular transport [inference]

endosomal transport [inference]

endocytic recycling

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport [inference]

endocytic recycling

maintenance of location [inference]

maintenance of protein location [inference]

cytoplasmic sequestering of protein [inference]

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

endocytic recycling

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity [inference]

cytoplasmic sequestering of NF-kappaB

cytoplasmic sequestering of transcription factor [inference]

cytoplasmic sequestering of NF-kappaB

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleoplasm	TAS
endosome	IEA
centrosome	IDA	26638075
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23563313 25355947 25416956 26496610 28514442 28892079 29778605 30833792 32296183 32838362 33060197 33961781 34232536 35271311 37172566
cullin family protein binding	IDA	23563313
cullin family protein binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cullin family protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Coiled-coil domain-containing protein 22

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
cullin family protein binding
positive regulation of ubiquitin-dependent protein catabolic process

Displaying **all 3** entries
InterPro
CCDC22, N-terminal domain
CCDC22, coiled-coil domain
Coiled-coil domain-containing protein 22

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060572	Ritscher-Schinzel syndrome 2	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	28952	Xenbase:XB-GENE-979496
Mus musculus	54638		MOUSE65441
Rattus norvegicus	317381		RATNO44934
Bos taurus	534246		BOVIN37062
Danio rerio	556259		DANRE42725
Macaca mulatta	713063		MACMU48489
Pan troglodytes	740863		PANTR45993
Equus caballus	100052164		HORSE44927
Salmo salar	100306834		SALSA26932
Pongo abelii	100434516		PONAB36771

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements