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Guidelines

MIRAGE

alanyl aminopeptidase, membrane

Summary

Gene Symbol

ANPEP

Organism

Homo sapiens (human)

External Links

NCBI Gene

290

PubChem

290

Alliance of Genome Resources

HGNC:500

Annotation

Keyword

3D-structure
Aminopeptidase
Angiogenesis
Cell membrane
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Metal-binding
Metalloprotease
Reference proteome
Signal-anchor
Sulfation
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q59E93
P15144	Alanyl aminopeptidase Aminopeptidase M Microsomal aminopeptidase Myeloid plasma membrane glycoprotein CD13 gp150

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
angiogenesis	IEA
angiotensin maturation	IEA
proteolysis	IBA
cell differentiation	IEA
peptide catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

peptide catabolic process

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	25645918
extracellular space	IBA
extracellular space	HDA	16502470
cytoplasm	IBA
lysosomal membrane	HDA	17897319

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

secretory granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum-Golgi intermediate compartment

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum-Golgi intermediate compartment

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
virus receptor activity	IEA
aminopeptidase activity	TAS	10734069
metallopeptidase activity	TAS	2564851
zinc ion binding	IBA
obsolete cytosol alanyl aminopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

binding [inference]

protein binding [inference]

exogenous protein binding [inference]

virus receptor activity

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aminopeptidase A

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 9** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
peptide catabolic process
proteolysis
zinc ion binding

Displaying **all 7** entries
InterPro
Aminopeptidase N-like , N-terminal domain superfamliy
Aminopeptidase N-like , N-terminal domain
Aminopeptidase N-type
ERAP1-like C-terminal domain
Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Peptidase M1, membrane alanine aminopeptidase
Peptidase M4/M1, CTD superfamily

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	290	Xenbase:XB-GENE-981369
Saccharomyces cerevisiae S288C	2028	SGD:S000001399
Saccharomyces cerevisiae S288C	4012	SGD:S000001399
Saccharomyces cerevisiae S288C	13809	SGD:S000001399
Mus musculus	16790	Xenbase:XB-GENE-981369	MOUSE53801
Saccharomyces cerevisiae S288C	29953	SGD:S000001399
Saccharomyces cerevisiae S288C	51752	SGD:S000001399
Saccharomyces cerevisiae S288C	64017	SGD:S000001399
Saccharomyces cerevisiae S288C	64167	SGD:S000001399
Saccharomyces cerevisiae S288C	80898	SGD:S000001399

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Supported by JST NBDC Grant Number JPMJND2204

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025