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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glutamate ionotropic receptor NMDA type subunit 2B
Summary
- Gene Symbol
-
- GRIN2B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Cell membrane
- Chromosomal rearrangement
- Cytoskeleton
- Disease variant
- Disulfide bond
- Endosome
- Epilepsy
- Glycoprotein
- Intellectual disability
- Ligand-gated ion channel
- Lysosome
- Magnesium
- Metal-binding
- Phosphoprotein
- Postsynaptic cell membrane
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A8D9PHB2 |
|
| Q13224 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| monoatomic cation transmembrane transport | ||
| positive regulation of excitatory postsynaptic potential | ||
| positive regulation of synaptic transmission, glutamatergic | ||
| positive regulation of cysteine-type endopeptidase activity |
|
|
| glutamate receptor signaling pathway |
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| postsynaptic membrane | ||
| postsynaptic density membrane | ||
| postsynaptic density | ||
| late endosome | ||
| NMDA selective glutamate receptor complex |
| GO Term | Evidence Code | PMID |
|---|---|---|
| glycine binding | ||
| protein binding | ||
| zinc ion binding | ||
| ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | ||
| glutamate-gated calcium ion channel activity |
GO Hierarchy
molecular function
transporter activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ligand-gated monoatomic ion channel activity |
| monoatomic ion transport |
| InterPro |
|---|
| Periplasmic binding protein-like I |
| Receptor, ligand binding region |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050696 | fetal alcohol spectrum disorder | |
| DOID:0050742 | nicotine dependence | |
| DOID:0060001 | withdrawal disorder | |
| DOID:0060037 | developmental disorder of mental health | |
| DOID:0070036 | autosomal dominant intellectual developmental disorder 6 | |
| DOID:0080444 | developmental and epileptic encephalopathy 27 | |
| DOID:10584 | retinitis pigmentosa | |
| DOID:10652 | Alzheimer's disease | |
| DOID:1094 | attention deficit hyperactivity disorder | |
| DOID:11206 | opioid abuse |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 14812 | MGI:95821 | MOUSE49741 | ||
| 24410 | RGD:2738 | RATNO30967 | ||
| 31107 | FB:FBgn0053513 | |||
| 180002 | WB:WBGene00003775 | |||
| 473373 | 9598_0:003617 | PANTR05251 | ||
| 494009 | CANLF11036 | |||
| 537804 | BOVIN30200 | |||
| 559976 | ZFIN:ZDB-GENE-061207-27 | |||
| 698571 | MACMU04323 | |||
| 751956 | TAEGU08387 |
