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MIRAGE
glutamate ionotropic receptor NMDA type subunit 2B
Summary
- Gene Symbol
-
- GRIN2B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Cell membrane
- Chromosomal rearrangement
- Cytoskeleton
- Disease variant
- Disulfide bond
- Endosome
- Epilepsy
- Glycoprotein
- Intellectual disability
- Ligand-gated ion channel
- Lysosome
- Magnesium
- Metal-binding
- Phosphoprotein
- Postsynaptic cell membrane
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A8D9PHB2 |
|
| Q13224 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| glutamate receptor signaling pathway | ||
| chemical synaptic transmission | ||
| brain development | ||
| learning or memory | ||
| calcium-mediated signaling |
GO Hierarchy
biological process
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasm | ||
| lysosome | ||
| late endosome | ||
| endoplasmic reticulum membrane | ||
| cytoskeleton |
| GO Term | Evidence Code | PMID |
|---|---|---|
| amyloid-beta binding | ||
| NMDA glutamate receptor activity | ||
| NMDA glutamate receptor activity | ||
| NMDA glutamate receptor activity | ||
| NMDA glutamate receptor activity |
GO Hierarchy
molecular function
transporter activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- glutamate
- Functional Category
-
- E: Amino acid transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ligand-gated monoatomic ion channel activity |
| monoatomic ion transport |
| InterPro |
|---|
| Periplasmic binding protein-like I |
| Receptor, ligand binding region |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050742 | nicotine dependence | |
| DOID:0070036 | autosomal dominant intellectual developmental disorder 6 | |
| DOID:0080444 | developmental and epileptic encephalopathy 27 | |
| DOID:10652 | Alzheimer's disease | |
| DOID:12858 | Huntington's disease | |
| DOID:1574 | alcohol use disorder | |
| DOID:3083 | chronic obstructive pulmonary disease | |
| DOID:3312 | bipolar disorder | |
| DOID:5419 | schizophrenia |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 2903 | Xenbase:XB-GENE-949327 | ||
| 2904 | Xenbase:XB-GENE-949327 | ||
| 2905 | FB:FBgn0053513 | ||
| 2906 | FB:FBgn0053513 | ||
| 14811 | Xenbase:XB-GENE-949327 | ||
| 14812 | Xenbase:XB-GENE-949327 | MOUSE49741 | |
| 14813 | FB:FBgn0053513 | ||
| 14814 | FB:FBgn0053513 | ||
| 24409 | Xenbase:XB-GENE-949327 | ||
| 24410 | Xenbase:XB-GENE-949327 | RATNO30967 |
