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glutamate ionotropic receptor NMDA type subunit 2C

Summary

Gene Symbol

GRIN2C

Organism

Homo sapiens (human)

External Links

NCBI Gene

2905

PubChem

2905

Alliance of Genome Resources

HGNC:4587

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Magnesium
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q14957	Glutamate [NMDA] receptor subunit epsilon-3 N-methyl D-aspartate receptor subtype 2C
H0Y2V8
A0A8D9PH81
O15398
Q8IW23

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
monoatomic cation transmembrane transport	ISS
response to wounding	IEA
positive regulation of excitatory postsynaptic potential	ISO
positive regulation of synaptic transmission, glutamatergic	ISO
protein localization to postsynaptic membrane	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to postsynaptic membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to postsynaptic membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

locomotion [inference]

directional locomotion

response to stimulus [inference]

response to stress [inference]

response to wounding

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to postsynaptic membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

monoatomic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to postsynaptic membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to postsynaptic membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway

ionotropic glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of synaptic plasticity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
postsynaptic membrane	NAS	15317856
postsynaptic density membrane	IBA
NMDA selective glutamate receptor complex	IBA IDA ISS TAS	17526495 26875626 26919761
endoplasmic reticulum membrane	TAS
plasma membrane	IBA IDA ISS TAS	26875626 26919761

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

NMDA selective glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

NMDA selective glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

NMDA selective glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

NMDA selective glutamate receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11937501 30126976 32814053
glutamate-gated calcium ion channel activity	IDA	26875626
NMDA glutamate receptor activity	IBA IDA TAS	17526495 26919761
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

NMDA glutamate receptor activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

NMDA glutamate receptor activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

NMDA glutamate receptor activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

NMDA glutamate receptor activity

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

amide transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

salt transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

glutamate-gated calcium ion channel activity

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

glutamate receptor activity [inference]

glutamate-gated receptor activity [inference]

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ligand-gated monoatomic ion channel activity
monoatomic ion transport

Displaying **all 2** entries
InterPro
Periplasmic binding protein-like I
Receptor, ligand binding region

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060037	developmental disorder of mental health	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 52 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14813		MGI:95822	MOUSE06892
Rattus norvegicus	24411		RGD:2739	RATNO01745
Drosophila melanogaster	31107		FB:FBgn0053513
Caenorhabditis elegans	180002		WB:WBGene00003775
Pan troglodytes	454868	9598_0:004662		PANTR15368
Canis lupus familiaris	483302			CANLF18478
Bos taurus	535158			BOVIN14027
Macaca mulatta	699216			MACMU15049
Monodelphis domestica	100028018			MONDO10477
Equus caballus	100052410			HORSE04099

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements