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transmembrane O-mannosyltransferase targeting cadherins 4

Summary

Gene Symbol

Tmtc4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

290501

KEGG Gene ID

rno:290501

PubChem

290501

Alliance of Genome Resources

RGD:1560183

Annotation

Keyword

Proteomics identification
Reference proteome
Repeat
TPR repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A8I6ADK7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sensory perception of sound	ISO
positive regulation of endoplasmic reticulum calcium ion concentration	ISO
outer hair cell apoptotic process	ISO
protein O-linked mannosylation	IBA ISO
endoplasmic reticulum unfolded protein response	IBA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

mannosylation [inference]

protein mannosylation [inference]

protein O-linked mannosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

outer hair cell apoptotic process

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IEA
endoplasmic reticulum	IBA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mannosyltransferase activity	IBA
dolichyl-phosphate-mannose-protein mannosyltransferase activity	ISO
ATPase binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity

dolichyl-phosphate-mannose-protein mannosyltransferase activity

catalytic activity, acting on a protein [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

ATPase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

protein O-mannosyl-transferase TMTC4

Functional Category

I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
dolichyl-phosphate-mannose-protein mannosyltransferase activity
endoplasmic reticulum unfolded protein response
mannosyltransferase activity
protein O-linked mannosylation

Displaying **all 3** entries
InterPro
Protein O-mannosyl-transferase TMTC, DUF1736
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

KEGG BRITE Database

Orthology

K23424

Name

protein O-mannosyl-transferase [EC:2.4.1.-]

References

28973932

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050565	autosomal recessive nonsyndromic deafness	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **123** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Oreochromis niloticus	100691018		ORENI22222
Cavia porcellus	100722385	10141_0:00440d	CAVPO02416
Cricetulus griseus	100766112	10029_0:000e37	CRIGR10865
Sarcophilus harrisii	100933825		SARHA14596
Otolemur garnettii	100963934		OTOGA12212
Pan paniscus	100991268		PANPA11329
Papio anubis	100997669		PAPAN10898
Saimiri boliviensis boliviensis	101033782		SAIBB13850
Takifugu rubripes	101065728		TAKRU25792
Felis catus	101081355		FELCA00073