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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
glutamate ionotropic receptor NMDA type subunit 2D
Summary
- Gene Symbol
-
- GRIN2D
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Cell membrane
- Disease variant
- Disulfide bond
- Epilepsy
- Glycoprotein
- Ligand-gated ion channel
- Magnesium
- Methylation
- Phosphoprotein
- Postsynaptic cell membrane
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| monoatomic cation transmembrane transport | ||
| positive regulation of excitatory postsynaptic potential | ||
| positive regulation of synaptic transmission, glutamatergic | ||
| regulation of sensory perception of pain | ||
| brain development |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| postsynaptic membrane | ||
| postsynaptic density membrane | ||
| NMDA selective glutamate receptor complex | ||
| endoplasmic reticulum membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | ||
| glutamate-gated calcium ion channel activity | ||
| NMDA glutamate receptor activity | ||
| glutamate binding |
GO Hierarchy
molecular function
transporter activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ligand-gated monoatomic ion channel activity |
| monoatomic ion transport |
| InterPro |
|---|
| Periplasmic binding protein-like I |
| Receptor, ligand binding region |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060037 | developmental disorder of mental health | |
| DOID:0080456 | developmental and epileptic encephalopathy 46 | |
| DOID:1826 | epilepsy | |
| DOID:5419 | schizophrenia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 14814 | MGI:95823 | |||
| 24412 | RGD:2740 | |||
| 31107 | FB:FBgn0053513 | |||
| 180002 | WB:WBGene00003775 | |||
| 449864 | ZFIN:ZDB-GENE-041008-124 | |||
| 456180 | 9598_0:004a6c | |||
| 618181 | BOVIN11433 | |||
| 717945 | MACMU17904 | |||
| 100084653 | ORNAN00743 | |||
| 100126609 | Xenbase:XB-GENE-1021543 |
