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ORMDL sphingolipid biosynthesis regulator 2

Summary

Gene Symbol

ORMDL2

Aliases

HSPC160
MST095
MSTP095
adoplin-2

Organism

Homo sapiens (human)

External Links

NCBI Gene

29095

HGNC

16037

KEGG Gene ID

hsa:29095

PubChem

29095

Alliance of Genome Resources

HGNC:16037

Annotation

Keyword

Endoplasmic reticulum
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q53FV1	Adoplin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ceramide metabolic process	IBA IMP	20182505
intracellular sphingolipid homeostasis	IBA
negative regulation of ceramide biosynthetic process	IMP	25691431
sphingolipid biosynthetic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular sphingolipid homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular sphingolipid homeostasis

lipid homeostasis [inference]

intracellular sphingolipid homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of cellular component biogenesis [inference]

regulation of sphingolipid biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of sphingolipid biosynthetic process [inference]

negative regulation of ceramide biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	12093374
serine C-palmitoyltransferase complex	IBA
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

endoplasmic reticulum palmitoyltransferase complex [inference]

serine C-palmitoyltransferase complex

catalytic complex [inference]

transferase complex [inference]

palmitoyltransferase complex [inference]

endoplasmic reticulum palmitoyltransferase complex [inference]

serine C-palmitoyltransferase complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2841	asthma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements