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Rac GTPase activating protein 1

Summary

Gene Symbol

RACGAP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

29127

PubChem

29127

Alliance of Genome Resources

HGNC:9804

Annotation

Keyword

3D-structure
Acetylation
Cell division
Cell membrane
Coiled coil
Congenital dyserythropoietic anemia
Cytoplasmic vesicle
Cytoskeleton
Developmental protein
Disease variant
GTPase activation
Ion transport
Isopeptide bond
Lipid-binding
Metal-binding
Microtubule
Nucleus
Phosphoprotein
Reference proteome
Spermatogenesis
Ubl conjugation
Zinc
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2RE34
Q9H0H5	Male germ cell RacGap Protein CYK4 homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
mitotic cytokinesis	IC	18511905
mitotic cytokinesis	IDA	11085985 19468302
mitotic cytokinesis	IMP	16236794 23235882
mitotic cytokinesis	IBA
actomyosin contractile ring assembly	IMP	16129829

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

spindle midzone assembly [inference]

mitotic spindle midzone assembly

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

cytokinetic process [inference]

assembly of actomyosin apparatus involved in cytokinesis [inference]

actomyosin contractile ring assembly

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

spindle midzone assembly [inference]

mitotic spindle midzone assembly

mitotic cell cycle process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

actomyosin structure organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

sulfate transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

actomyosin structure organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actomyosin contractile ring organization [inference]

actomyosin contractile ring assembly

cellular component assembly [inference]

assembly of actomyosin apparatus involved in cytokinesis [inference]

actomyosin contractile ring assembly

spindle midzone assembly [inference]

mitotic spindle midzone assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

inorganic anion transport [inference]

sulfate transport

sulfate transmembrane transport

inorganic anion transmembrane transport [inference]

sulfate transmembrane transport

transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

sulfate transmembrane transport

nitrogen compound transport [inference]

sulfate transport

sulfate transmembrane transport

sulfur compound transport [inference]

sulfate transport

sulfate transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell division [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

regulation of attachment of spindle microtubules to kinetochore

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of embryonic development

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	IEA
nucleus	IDA	11085985 11782313 16103226 18445686
nucleus	IBA
nucleoplasm	IDA
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

centralspindlin complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

cleavage furrow

midbody

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular non-membrane-bounded organelle [inference]

spindle

mitotic spindle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol-3,4,5-trisphosphate binding	IDA	23235882
microtubule binding	IDA	11782313
zinc ion binding	IEA
protein kinase binding	IPI	19468302
protein-macromolecule adaptor activity	IDA	11782313

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Rac GTPase-activating protein

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
Rho protein signal transduction
metal ion binding
mitotic cytokinesis
mitotic spindle midzone assembly

Displaying **all 4** entries
InterPro
C1-like domain superfamily
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Rho GTPase activation protein
Rho GTPase-activating protein domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1338	congenital dyserythropoietic anemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	26934	Xenbase:XB-GENE-943983	MOUSE16381
Xenopus tropicalis	29127	Xenbase:XB-GENE-943983
Rattus norvegicus	315298		RATNO38642
Danio rerio	323197		DANRE25266
Pan troglodytes	451887		PANTR05914
Canis lupus familiaris	486549		CANLF10818
Bos taurus	514618		BOVIN29221
Macaca mulatta	711887		MACMU05177
Monodelphis domestica	100022945		MONDO34823
Equus caballus	100059818		HORSE36970