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granulin precursor

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29143

PubChem

29143

Alliance of Genome Resources

RGD:61983

Annotation

Keyword

Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 6** entries
UniProt	Protein Name
Q6IN42
A6HJK4
G3V8V1
P23785	Acrogranin Epithelin precursor Granulin precursor Proepithelin
F1LMP7
A6HJK0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 44 in total

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GO Term	Evidence Code	PMID
positive regulation of neuron projection development	IMP	21813674
negative regulation of respiratory burst involved in inflammatory response	IEA ISO ISS
embryo implantation	ISO
positive regulation of inflammatory response to wounding	ISO ISS
positive regulation of endothelial cell migration	ISO ISS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

glial cell activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

astrocyte activation [inference]

astrocyte activation involved in immune response

signal transduction

cell population proliferation [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure

synapse organization [inference]

maintenance of synapse structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure

reproductive process [inference]

embryo implantation

reproductive behavior [inference]

mating behavior [inference]

male mating behavior

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

glial cell activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

astrocyte activation [inference]

astrocyte activation involved in immune response

behavior [inference]

locomotory behavior [inference]

locomotory exploration behavior

reproductive behavior [inference]

mating behavior [inference]

male mating behavior

exploration behavior [inference]

locomotory exploration behavior

organism emergence from protective structure [inference]

hatching [inference]

blastocyst hatching

developmental process [inference]

anatomical structure development [inference]

retina development in camera-type eye

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to oxygen-containing compound [inference]

response to estradiol

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of aspartic-type peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of aspartic-type peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of respiratory burst [inference]

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of aspartic-type peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of trophectodermal cell proliferation [inference]

positive regulation of trophectodermal cell proliferation

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of protein folding

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of axon regeneration

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of response to wounding [inference]

positive regulation of developmental process [inference]

positive regulation of dendritic spine development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of metabolic process [inference]

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of respiratory burst involved in inflammatory response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of response to external stimulus [inference]

positive regulation of axon regeneration

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of axon regeneration [inference]

positive regulation of axon regeneration

regulation of inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response to wounding [inference]

positive regulation of inflammatory response to wounding

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of axon regeneration

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of response to wounding [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response to wounding [inference]

positive regulation of inflammatory response to wounding

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of response to wounding [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

regulation of inflammatory response to wounding [inference]

positive regulation of inflammatory response to wounding

positive regulation of response to wounding [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

regulation of cell differentiation [inference]

regulation of cell development [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of developmental growth [inference]

regulation of trophectodermal cell proliferation [inference]

positive regulation of trophectodermal cell proliferation

positive regulation of developmental process [inference]

positive regulation of dendritic spine development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of dendritic spine development [inference]

positive regulation of dendritic spine development

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of trophectodermal cell proliferation [inference]

positive regulation of trophectodermal cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cell differentiation [inference]

regulation of cell development [inference]

negative regulation of respiratory burst involved in inflammatory response

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of protein folding

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

regulation of vacuole organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

regulation of lysosome organization

positive regulation of lysosome organization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of protein folding [inference]

positive regulation of protein folding

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

negative regulation of hydrolase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of aspartic-type peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
presynapse	IEA
glutamatergic synapse	IDA	24046442
endoplasmic reticulum	IEA ISO ISS
trans-Golgi network	ISO ISS
cerebellar climbing fiber to Purkinje cell synapse	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

cell junction [inference]

synapse

excitatory synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

glutamatergic synapse

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

neuron to neuron synapse [inference]

asymmetric synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

late endosome

presynapse

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity	IEA
protein binding	IPI	17307734
protein-folding chaperone binding	IEA ISO ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

cytokine activity

protein-folding chaperone binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Granulin

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of inflammatory response

Displaying **all 3** entries
InterPro
Granulin family
Granulin superfamily
Granulin

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050784	primary progressive multiple sclerosis	Alliance of Genome Resources
DOID:0060672	Grn-related frontotemporal lobar degeneration with Tdp43 inclusions	Alliance of Genome Resources
DOID:0110732	neuronal ceroid lipofuscinosis 11	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:12387	nephrogenic diabetes insipidus	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2896		HGNC:4601	HUMAN34219
Mus musculus	14824	10090_1:00360b	MGI:95832	MOUSE05360
Caenorhabditis elegans	173054		WB:WBGene00011936
Danio rerio	335453		ZFIN:ZDB-GENE-030131-7393	DANRE25535
Pan troglodytes	454728			PANTR13732
Xenopus tropicalis	594884		Xenbase:XB-GENE-995710
Macaca mulatta	714851			MACMU14125
Sus scrofa	733645			PIGXX02157
Danio rerio	791524		ZFIN:ZDB-GENE-030131-8434
Monodelphis domestica	100023282			MONDO11216

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements