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solute carrier family 25 member 6

Summary

Gene Symbol

SLC25A6

Organism

Homo sapiens (human)

External Links

NCBI Gene

293

PubChem

293

Alliance of Genome Resources

HGNC:10992

Annotation

Keyword

Acetylation
Antiport
Apoptosis
Direct protein sequencing
Host-virus interaction
Methylation
Mitochondrion inner membrane
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6I9V5	ADP,ATP carrier protein
P12236	ADP,ATP carrier protein 3 ADP,ATP carrier protein, isoform T2 Adenine nucleotide translocator 3 Solute carrier family 25 member 6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IBA
mitochondrial ATP transmembrane transport	IEA
apoptotic process	IEA
mitochondrial ADP transmembrane transport	IEA

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

transmembrane transport [inference]

purine-containing compound transmembrane transport [inference]

nucleotide transmembrane transport [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

membrane organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

localization [inference]

establishment of localization [inference]

transport [inference]

mitochondrial transport [inference]

transmembrane transport [inference]

purine-containing compound transmembrane transport [inference]

nucleotide transmembrane transport [inference]

organic substance transport [inference]

organic anion transport [inference]

ADP transport [inference]

mitochondrial ADP transmembrane transport

ATP transport [inference]

mitochondrial ATP transmembrane transport

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

ADP transport [inference]

mitochondrial ADP transmembrane transport

ATP transport [inference]

mitochondrial ATP transmembrane transport

adenine nucleotide transport [inference]

ADP transport [inference]

mitochondrial ADP transmembrane transport

ATP transport [inference]

mitochondrial ATP transmembrane transport

nucleotide transmembrane transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

ADP transport [inference]

mitochondrial ADP transmembrane transport

ATP transport [inference]

mitochondrial ATP transmembrane transport

adenine nucleotide transport [inference]

ADP transport [inference]

mitochondrial ADP transmembrane transport

ATP transport [inference]

mitochondrial ATP transmembrane transport

nucleotide transmembrane transport [inference]

purine-containing compound transmembrane transport [inference]

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

ADP transport [inference]

mitochondrial ADP transmembrane transport

ATP transport [inference]

mitochondrial ATP transmembrane transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

ADP transport [inference]

mitochondrial ADP transmembrane transport

ATP transport [inference]

mitochondrial ATP transmembrane transport

adenine nucleotide transport [inference]

ADP transport [inference]

mitochondrial ADP transmembrane transport

ATP transport [inference]

mitochondrial ATP transmembrane transport

nucleotide transmembrane transport [inference]

purine-containing compound transmembrane transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrion organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of biological quality [inference]

regulation of membrane permeability [inference]

regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of membrane permeability [inference]

negative regulation of mitochondrial membrane permeability [inference]

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IDA	27641616
mitochondrial inner membrane	TAS
mitochondrion	HDA HTP IDA	20833797 34800366
TIM23 mitochondrial import inner membrane translocase complex	TAS	2541251
nucleus	HDA	21630459

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

TIM23 mitochondrial import inner membrane translocase complex

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

TIM23 mitochondrial import inner membrane translocase complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16201016 21370995 21516116 24725412 25416956 29128334 29892012
ATP:ADP antiporter activity	NAS	2541251

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

ATP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

ADP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

organophosphate ester transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

ATP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

ADP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

purine ribonucleotide transmembrane transporter activity [inference]

ATP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

ADP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

ATP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

ADP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

purine ribonucleotide transmembrane transporter activity [inference]

ATP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

ADP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

ATP:ADP antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

purine ribonucleotide transmembrane transporter activity [inference]

ATP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

ADP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

salt transmembrane transporter activity [inference]

ATP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

ADP transmembrane transporter activity [inference]

ATP:ADP antiporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Mitochondrial carrier domain superfamily
Mitochondrial carrier protein
Mitochondrial substrate/solute carrier

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080335	mitochondrial DNA depletion syndrome 12b	Alliance of Genome Resources
DOID:0111517	autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:700	mitochondrial metabolism disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32007	FB:FBgn0003360
Drosophila melanogaster	32008	FB:FBgn0025111
Caenorhabditis elegans	176773	WB:WBGene00006439
Caenorhabditis elegans	177648	WB:WBGene00020140
Caenorhabditis elegans	184917	WB:WBGene00017770
Caenorhabditis elegans	186855	WB:WBGene00010485
Caenorhabditis elegans	189112	WB:WBGene00007057
Bos taurus	282480		BOVIN21208
Xenopus tropicalis	394508	Xenbase:XB-GENE-6082577
Sus scrofa	403155		PIGXX38937

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements