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gelsolin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

2934

PubChem

2934

Alliance of Genome Resources

HGNC:4620

Annotation

Keyword

3D-structure
Acetylation
Actin capping
Actin-binding
Alternative initiation
Alternative splicing
Amyloid
Amyloidosis
Calcium
Cilium biogenesis/degradation
Corneal dystrophy
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease variant
Disulfide bond
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A0A0MT01	Actin-depolymerizing factor
P06396	AGEL Actin-depolymerizing factor Brevin
A0A0A0MS51	Actin-depolymerizing factor
B7Z4U6	Actin-depolymerizing factor
A0A384MEF1	Actin-depolymerizing factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
negative regulation of viral entry into host cell	IMP	23575248
regulation of receptor clustering	IMP	23575248
amyloid fibril formation	IMP	19904968 24601799
positive regulation of actin nucleation	IMP	19666531
relaxation of cardiac muscle	ISS	30568254

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

amyloid fibril formation

primary metabolic process [inference]

protein metabolic process [inference]

amyloid fibril formation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

amyloid fibril formation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

amyloid fibril formation

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

actin filament-based process [inference]

actin filament-based movement [inference]

actin-mediated cell contraction [inference]

cardiac muscle cell contraction

actin filament severing

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

sequestering of actin monomers

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component disassembly [inference]

extracellular matrix disassembly

protein-containing complex disassembly [inference]

protein depolymerization [inference]

actin filament depolymerization

cellular component assembly [inference]

cell projection assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

actin filament depolymerization

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment

supramolecular fiber organization [inference]

actin filament organization

actin polymerization or depolymerization

amyloid fibril formation

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle adaptation [inference]

striated muscle adaptation [inference]

striated muscle atrophy

muscle atrophy [inference]

striated muscle atrophy

relaxation of muscle [inference]

relaxation of cardiac muscle

renal system process [inference]

renal absorption [inference]

renal protein absorption

developmental process [inference]

anatomical structure development [inference]

system development [inference]

central nervous system development

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to muscle stretch

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to muscle stretch

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

muscle adaptation [inference]

striated muscle adaptation [inference]

striated muscle atrophy

muscle atrophy [inference]

striated muscle atrophy

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

localization [inference]

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in cell [inference]

sequestering of actin monomers

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

sequestering of actin monomers

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering

regulation of plasma membrane raft polarization

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of keratinocyte apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

negative regulation of viral process [inference]

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of protein processing in phagocytic vesicle [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

regulation of establishment or maintenance of cell polarity [inference]

regulation of establishment of cell polarity [inference]

regulation of establishment of T cell polarity

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

regulation of actin nucleation [inference]

positive regulation of actin nucleation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of keratinocyte apoptotic process

regulation of epithelial cell apoptotic process [inference]

regulation of keratinocyte apoptotic process [inference]

positive regulation of keratinocyte apoptotic process

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of keratinocyte apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of keratinocyte apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of podosome assembly

regulation of organelle assembly [inference]

regulation of podosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

positive regulation of protein processing in phagocytic vesicle

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of keratinocyte apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

regulation of actin nucleation [inference]

positive regulation of actin nucleation

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation

regulation of organelle assembly [inference]

regulation of podosome assembly

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of podosome assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

regulation of actin nucleation [inference]

positive regulation of actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation

regulation of plasma membrane organization [inference]

regulation of plasma membrane raft polarization

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering

regulation of plasma membrane raft polarization

regulation of biological quality [inference]

regulation of protein stability [inference]

protein destabilization

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

sequestering of actin monomers

actin filament capping

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping

barbed-end actin filament capping

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of cysteine-type endopeptidase activity [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
secretory granule lumen	TAS
focal adhesion	HDA	21423176
actin cap	IDA	23575248
cortical actin cytoskeleton	IDA	23575248 24236012
plasma membrane	IDA	23575248

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

sarcoplasm

cytosol

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

actin cap

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

ficolin-1-rich granule lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10793131 16531231 17470807 17620599 18689676 19015515 19574450 19666512 23325791 29961565 32814053
actin binding	IDA	18266911 24236012
actin filament binding	IBA
phosphatidylinositol 3-kinase catalytic subunit binding	IPI	30568254
phosphatidylinositol-4,5-bisphosphate binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

myosin binding [inference]

myosin II binding

enzyme binding [inference]

kinase binding [inference]

phosphatidylinositol 3-kinase catalytic subunit binding

phosphatidylinositol 3-kinase binding [inference]

phosphatidylinositol 3-kinase catalytic subunit binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

VILLIN

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
actin binding
actin filament binding
actin filament severing
actin polymerization or depolymerization
barbed-end actin filament capping
phosphatidylinositol-4,5-bisphosphate binding

Displaying **all 3** entries
InterPro
ADF-H/Gelsolin-like domain superfamily
Gelsolin-like domain
Villin/Gelsolin

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050637	Finnish type amyloidosis	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:8481	rheumatic myocarditis	Alliance of Genome Resources
DOID:850	lung disease	Alliance of Genome Resources
DOID:9159	gas gangrene	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35058		FB:FBgn0003187
Drosophila melanogaster	46008		FB:FBgn0010225
Caenorhabditis elegans	179328		WB:WBGene00010593
Mus musculus	227753		MGI:95851	MOUSE35523
Rattus norvegicus	296654		RGD:1303089	RATNO28233
Danio rerio	321099		ZFIN:ZDB-GENE-030131-9653	DANRE21498
Danio rerio	336623		ZFIN:ZDB-GENE-030131-8567
Xenopus laevis	397895		Xenbase:XB-GENE-865877
Pan troglodytes	464706	9598_0:00289d		PANTR44720
Canis lupus familiaris	474819			CANLF02500

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements