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hydroxysteroid (17-beta) dehydrogenase 7

Summary

Gene Symbol

Hsd17b7

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29540

PubChem

29540

Alliance of Genome Resources

RGD:2837

Annotation

Keyword

Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
NAD
NADP
Oxidoreductase
Reference proteome
Steroid biosynthesis
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6IDN2
A0A0H2UHB1
Q62904	17-beta-hydroxysteroid dehydrogenase 7 3-keto-steroid reductase Dihydrotestosterone oxidoreductase Estradiol 17-beta-dehydrogenase 7 PRL receptor-associated protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 15 in total

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GO Term	Evidence Code	PMID
hippocampus development	IEP	21047951
response to xenobiotic stimulus	IEP	9231770
brain development	ISO
nervous system development	ISO
androgen metabolic process	IEA ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

estrogen biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

hormone metabolic process [inference]

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

cellular process [inference]

cellular developmental process [inference]

cell differentiation

reproductive process [inference]

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy

developmental process [inference]

anatomical structure development [inference]

hippocampus development

animal organ development [inference]

system development [inference]

skeletal system development [inference]

embryonic skeletal system development

nervous system development

cellular developmental process [inference]

cell differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to prolactin

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to prolactin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to prolactin

response to organic cyclic compound

response to estradiol

response to lipid [inference]

response to estradiol

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to prolactin

response to oxygen-containing compound [inference]

response to estradiol

response to peptide [inference]

response to peptide hormone [inference]

response to prolactin

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA IEA ISO ISS
mitochondrion	ISO	34800366
endoplasmic reticulum	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
3-keto sterol reductase activity	IBA IEA ISO ISS
estradiol 17-beta-dehydrogenase [NAD(P)] activity	IBA IDA IEA ISO	9658408
prolactin receptor binding	IPI	8663045
5alpha-androstane-3beta,17beta-diol dehydrogenase activity	IBA IEA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-keto sterol reductase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

prolactin receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
5alpha-androstane-3beta,17beta-diol dehydrogenase activity
cholesterol biosynthetic process
estradiol 17-beta-dehydrogenase [NAD(P)] activity
oxidoreductase activity
steroid biosynthetic process

Displaying **all 3** entries
InterPro
3-keto-steroid reductase
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:11612	polycystic ovary syndrome	Alliance of Genome Resources
DOID:1701	steroid inherited metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **106** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Monodelphis domestica	100016071		MONDO12299
Equus caballus	100059061		HORSE35645
Sus scrofa	100155418		PIGXX23623
Callithrix jacchus	100410416		CALJA16621
Pongo abelii	100446761		PONAB17936
Ailuropoda melanoleuca	100477716		AILME11902
Meleagris gallopavo	100542640		MELGA02173
Anolis carolinensis	100556465		ANOCA15568
Nomascus leucogenys	100587120		NOMLE05204
Cavia porcellus	100729809	10141_0:002113	CAVPO15368