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Guidelines

MIRAGE

mutS homolog 6

Summary

Gene Symbol

MSH6

Organism

Homo sapiens (human)

External Links

NCBI Gene

2956

PubChem

2956

Alliance of Genome Resources

HGNC:7329

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Chromosome
DNA repair
DNA-binding
Direct protein sequencing
Disease variant
Hereditary nonpolyposis colorectal cancer
Host-virus interaction
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3SWU9
P52701	G/T mismatch-binding protein MutS protein homolog 6 MutS-alpha 160 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 17** of 17 in total

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GO Term	Evidence Code	PMID
positive regulation of helicase activity	IDA	17715146
intrinsic apoptotic signaling pathway	ISS

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic diversification of immune receptors via somatic mutation [inference]

somatic hypermutation of immunoglobulin genes

somatic diversification of immunoglobulins [inference]

somatic diversification of immunoglobulins involved in immune response [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic hypermutation of immunoglobulin genes

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway

intrinsic apoptotic signaling pathway in response to DNA damage

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

intrinsic apoptotic signaling pathway in response to DNA damage

cell cycle process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

meiotic mismatch repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

mismatch repair

meiotic mismatch repair

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

maintenance of DNA repeat elements

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

mismatch repair

meiotic mismatch repair

intrinsic apoptotic signaling pathway in response to DNA damage

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

maintenance of DNA repeat elements

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

meiotic mismatch repair

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

determination of adult lifespan

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

mismatch repair

meiotic mismatch repair

intrinsic apoptotic signaling pathway in response to DNA damage

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

mismatch repair

meiotic mismatch repair

intrinsic apoptotic signaling pathway in response to DNA damage

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway

intrinsic apoptotic signaling pathway in response to DNA damage

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway

intrinsic apoptotic signaling pathway in response to DNA damage

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA recombination

regulation of molecular function [inference]

regulation of ATP-dependent activity [inference]

positive regulation of ATP-dependent activity [inference]

positive regulation of helicase activity

regulation of helicase activity [inference]

positive regulation of helicase activity

positive regulation of molecular function [inference]

positive regulation of ATP-dependent activity [inference]

positive regulation of helicase activity

positive regulation of catalytic activity [inference]

positive regulation of helicase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of helicase activity

regulation of helicase activity [inference]

positive regulation of helicase activity

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
chromatin	IEA
nucleus	IDA	26300262
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

mismatch repair complex [inference]

MutSalpha complex

protein-DNA complex [inference]

chromatin

nuclear protein-containing complex [inference]

MutSalpha complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA	16403449
four-way junction DNA binding	IDA	12034830
chromatin binding	IEA
damaged DNA binding
double-stranded DNA binding	IDA	11809883

GO Hierarchy

molecular function

catalytic activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA

ATP-dependent DNA damage sensor activity

binding [inference]

protein binding

enzyme binding

histone binding [inference]

methylated histone binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

modification-dependent protein binding [inference]

methylation-dependent protein binding [inference]

methylated histone binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

protein-containing complex binding [inference]

chromatin binding

mismatch repair complex binding [inference]

MutLalpha complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

DNA secondary structure binding [inference]

four-way junction DNA binding

damaged DNA binding

oxidized DNA binding [inference]

oxidized purine DNA binding

double-stranded DNA binding

mismatched DNA binding

DNA insertion or deletion binding [inference]

single base insertion or deletion binding [inference]

guanine/thymine mispair binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

small molecule sensor activity [inference]

DNA damage sensor activity [inference]

ATP-dependent DNA damage sensor activity

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA

ATP-dependent DNA damage sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA mismatch repair

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
ATP-dependent DNA damage sensor activity
DNA repair
nucleotide binding

Displaying entries **1 - 10** of 11 in total

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InterPro
DNA mismatch repair MutS family
DNA mismatch repair protein MutS, C-terminal
DNA mismatch repair protein MutS, N-terminal
DNA mismatch repair protein MutS, clamp
DNA mismatch repair protein MutS, connector domain
DNA mismatch repair protein MutS, core domain superfamily
DNA mismatch repair protein MutS, core
DNA mismatch repair protein MutS-like, N-terminal
DNA mismatch repair protein MutS/MSH
MutS, connector domain superfamily

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0070272	hereditary nonpolyposis colorectal cancer type 5	Alliance of Genome Resources
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:0112182	mismatch repair cancer syndrome	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:3883	Lynch syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Oryctolagus cuniculus	100351645		RABIT08658
Rattus norvegicus	100360342		RATNO35107
Callithrix jacchus	100386465		CALJA11210
Pongo abelii	100458732		PONAB23012
Ailuropoda melanoleuca	100471984		AILME19657
Meleagris gallopavo	100541959		MELGA05465
Anolis carolinensis	100562407		ANOCA01942
Nomascus leucogenys	100593553		NOMLE09146
Sus scrofa	100624450		PIGXX22114
Loxodonta africana	100677382		LOXAF06888

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Last updated: April 7, 2025