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gamma-aminobutyric acid type A receptor subunit alpha6

Summary

Gene Symbol

Gabra6

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29708

PubChem

29708

Alliance of Genome Resources

RGD:61861

Annotation

Keyword

Cell membrane
Chloride channel
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6HDL7
P30191	GABA(A) receptor subunit alpha-6

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of postsynaptic membrane potential	IBA IEA
synaptic transmission, GABAergic	IBA IMP	16554486
chloride transmembrane transport	IBA IEA
response to ethanol	IEP	23413777
gamma-aminobutyric acid signaling pathway	IBA IEA NAS	34417930

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

synapse organization [inference]

synapse assembly [inference]

inhibitory synapse assembly

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to alcohol [inference]

response to ethanol

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

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GO Term	Evidence Code	PMID
postsynaptic membrane	IDA	8613776
postsynapse	IBA
postsynaptic specialization membrane	IDA IEA	8613776 9464994
receptor complex	IDA	14713300
GABA-A receptor complex	IBA ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

GABA receptor complex [inference]

GABA-A receptor complex

membrane protein complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane [inference]

cell junction [inference]

synapse

GABA-ergic synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

cerebellar Golgi cell to granule cell synapse

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

cell body membrane [inference]

neuronal cell body membrane

postsynapse

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GO Term	Evidence Code	PMID
protein-containing complex binding	IPI	14713300
heterocyclic compound binding	IDA	2166916
inhibitory extracellular ligand-gated monoatomic ion channel activity	IMP	16554486
neurotransmitter receptor activity	IBA
benzodiazepine receptor activity	IBA IMP	16554486

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding

protein-containing complex binding

organic cyclic compound binding [inference]

diazepam binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

GABA receptor activity [inference]

GABA-A receptor activity

neurotransmitter receptor activity

benzodiazepine receptor activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

gamma-aminobutyric acid receptor subunit alpha-6

Functional Category

H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

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Gene Ontology
GABA-A receptor activity
GABA-gated chloride ion channel activity
benzodiazepine receptor activity
chloride channel activity
chloride transmembrane transport
chloride transport
extracellular ligand-gated monoatomic ion channel activity
gamma-aminobutyric acid signaling pathway
inhibitory extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity

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InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain
Gamma-aminobutyric-acid A receptor, alpha 6 subunit
Gamma-aminobutyric-acid A receptor, alpha subunit
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
presynaptic membrane	PMID:17303643
receptor complex	PMID:14713300
neuronal cell body membrane	PMID:8613776
dendrite	PMID:8613776
postsynaptic membrane	PMID:8613776

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **124** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2559		HGNC:4080	HUMAN82103
Mus musculus	14399	10090_1:003a02	MGI:95618	MOUSE04109
Drosophila melanogaster	32553		FB:FBgn0030707
Caenorhabditis elegans	176694		WB:WBGene00013914
Pan troglodytes	471725			PANTR36743
Danio rerio	559693		ZFIN:ZDB-GENE-080815-1	DANRE22000
Macaca mulatta	697010			MACMU39473
Caenorhabditis elegans	3565335		WB:WBGene00008551
Monodelphis domestica	100030493			MONDO07161
Equus caballus	100070890			HORSE09035