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gamma-aminobutyric acid type A receptor subunit alpha6

Summary

Gene Symbol

Gabra6

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29708

PubChem

29708

Alliance of Genome Resources

RGD:61861

Annotation

Keyword

Cell membrane
Chloride channel
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6HDL7
P30191	GABA(A) receptor subunit alpha-6

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of postsynaptic membrane potential	IBA IEA
synaptic transmission, GABAergic	IBA IMP	16554486
chloride transmembrane transport	IBA IEA
response to ethanol	IEP	23413777
gamma-aminobutyric acid signaling pathway	IBA IEA NAS	34417930

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

inhibitory synapse assembly

synapse organization [inference]

synapse assembly [inference]

inhibitory synapse assembly

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to alcohol [inference]

response to ethanol

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

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GO Term	Evidence Code	PMID
neuronal cell body membrane	IDA	8613776
plasma membrane	IBA IDA	9464994
hippocampal mossy fiber to CA3 synapse	IDA	8613776
neuron projection	IBA
dendrite	IDA	8613776

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

GABA receptor complex [inference]

GABA-A receptor complex

membrane protein complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

synaptic membrane [inference]

cell junction [inference]

synapse

GABA-ergic synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

cerebellar Golgi cell to granule cell synapse

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

cell body membrane [inference]

neuronal cell body membrane

postsynapse

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GO Term	Evidence Code	PMID
diazepam binding	IDA	2166916
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA ISO
GABA-A receptor activity	IBA IDA IEA	17395622
chloride channel activity	IBA IEA
GABA-gated chloride ion channel activity	IMP	17395622

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

inhibitory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic anion channel activity [inference]

GABA-gated chloride ion channel activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

GABA-gated chloride ion channel activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding

protein-containing complex binding

organic cyclic compound binding [inference]

diazepam binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

GABA receptor activity [inference]

GABA-A receptor activity

neurotransmitter receptor activity

benzodiazepine receptor activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

gamma-aminobutyric acid receptor subunit alpha-6

Functional Category

H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

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Gene Ontology
GABA-A receptor activity
GABA-gated chloride ion channel activity
benzodiazepine receptor activity
chloride channel activity
chloride transmembrane transport
chloride transport
extracellular ligand-gated monoatomic ion channel activity
gamma-aminobutyric acid signaling pathway
inhibitory extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity

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InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain
Gamma-aminobutyric-acid A receptor, alpha 6 subunit
Gamma-aminobutyric-acid A receptor, alpha subunit
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
presynaptic membrane	PMID:17303643
receptor complex	PMID:14713300
neuronal cell body membrane	PMID:8613776
dendrite	PMID:8613776
postsynaptic membrane	PMID:8613776

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **124** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2559		HGNC:4080	HUMAN82103
Mus musculus	14399	10090_1:003a02	MGI:95618	MOUSE04109
Drosophila melanogaster	32553		FB:FBgn0030707
Caenorhabditis elegans	176694		WB:WBGene00013914
Pan troglodytes	471725			PANTR36743
Danio rerio	559693		ZFIN:ZDB-GENE-080815-1	DANRE22000
Macaca mulatta	697010			MACMU39473
Caenorhabditis elegans	3565335		WB:WBGene00008551
Monodelphis domestica	100030493			MONDO07161
Equus caballus	100070890			HORSE09035