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Standards Ontologies Notations
sodium voltage-gated channel alpha subunit 8

Summary
Gene Symbol
  • Scn8a
Organism
Rattus norvegicus (Norway rat)
NCBI Gene
29710
PubChem
29710
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Disulfide bond
  • Glycoprotein
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Sodium channel
  • Transmembrane helix
  • Ubl conjugation
  • Voltage-gated channel
Proteins
Displaying 1 entry
UniProt Protein Name
O88420
  • Peripheral nerve protein type 4
  • Sodium channel 6
  • Sodium channel protein type VIII subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.6
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 11 - 15 of 15 in total
GO Term Evidence Code PMID
locomotory behavior
sodium ion transmembrane transport
nerve development
adult walking behavior
muscle organ development
GO Hierarchy
Displaying all 3 entries
GO Term Evidence Code PMID
protein binding
sodium ion binding
voltage-gated sodium channel activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Rodentia
Group Name
sodium channel protein type 8 subunit alpha
Functional Category
  • G: Carbohydrate transport and metabolism
  • K: Transcription
  • T: Signal transduction mechanisms
Displaying all 8 entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
nervous system process
neuronal action potential
sodium channel activity
sodium ion transmembrane transport
voltage-gated sodium channel activity
Displaying all 9 entries
InterPro
IQ motif, EF-hand binding site
Ion transport domain
Sodium ion transport-associated domain
Voltage gated sodium channel, alpha subunit
Voltage gated sodium channel, alpha-8 subunit
Voltage-dependent channel domain superfamily
Voltage-gated Na+ ion channel, cytoplasmic domain
Voltage-gated cation channel calcium and sodium
Voltage-gated sodium channel alpha subunit, inactivation gate
Disease
Disease Ontology
Displaying all 8 entries
DO ID Disease Name Source
DOID:0050709 early infantile epileptic encephalopathy
DOID:0060170 generalized epilepsy with febrile seizures plus
DOID:0080422 Dravet syndrome
DOID:0080445 developmental and epileptic encephalopathy 13
DOID:0081118 benign familial infantile seizures 5
DOID:0111294 generalized epilepsy with febrile seizures plus 2
DOID:1826 epilepsy
DOID:6000 congestive heart failure
Ortholog
Displaying entries 11 - 20 of 132 in total
Species Gene ID OrthoDB Alliance of Genome Resources Orthologous MAtrix
853131 SGD:S000003449
100080468 ORNAN01711
100304602 ICTPU02006
100349067 RABIT10347
100390284 CALJA45633
100451262 PONAB06192
100477325 AILME10395
100522189 PIGXX25319
100556690 ANOCA02758
100579962 NOMLE35419
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024