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sodium voltage-gated channel alpha subunit 8

Summary

Gene Symbol

Scn8a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29710

PubChem

29710

Alliance of Genome Resources

RGD:3638

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
O88420	Peripheral nerve protein type 4 Sodium channel 6 Sodium channel protein type VIII subunit alpha Voltage-gated sodium channel subunit alpha Nav1.6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 15 in total

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GO Term	Evidence Code	PMID
locomotory behavior	ISO
sodium ion transmembrane transport	IBA IEA
nerve development	ISO
adult walking behavior	ISO
muscle organ development	ISO

GO Hierarchy

biological process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

behavior [inference]

locomotory behavior

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

developmental process [inference]

anatomical structure development [inference]

nerve development

cranial nerve development [inference]

optic nerve development

animal organ development [inference]

muscle organ development

system development [inference]

peripheral nervous system development

muscle structure development [inference]

muscle organ development

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential [inference]

action potential

neuronal action potential

membrane depolarization [inference]

membrane depolarization during action potential

Displaying entries **11 - 15** of 15 in total

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GO Term	Evidence Code	PMID
axon	IBA IDA	21118538
node of Ranvier	IDA ISO	16652168
presynaptic active zone membrane	IDA	10779552
Z disc	ISO
glutamatergic synapse	IDA	10779552

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic active zone membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

Z disc

cell junction

synapse [inference]

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

glutamatergic synapse

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon initial segment

cell body [inference]

neuronal cell body

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15282281
sodium ion binding	IEA ISO
voltage-gated sodium channel activity	IBA IC IDA IEA IMP ISO	15917456 17273863 9603190

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

alkali metal ion binding [inference]

sodium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

sodium channel protein type 8 subunit alpha

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
nervous system process
neuronal action potential
sodium channel activity
sodium ion transmembrane transport
voltage-gated sodium channel activity

Displaying **all 9** entries
InterPro
IQ motif, EF-hand binding site
Ion transport domain
Sodium ion transport-associated domain
Voltage gated sodium channel, alpha subunit
Voltage gated sodium channel, alpha-8 subunit
Voltage-dependent channel domain superfamily
Voltage-gated Na+ ion channel, cytoplasmic domain
Voltage-gated cation channel calcium and sodium
Voltage-gated sodium channel alpha subunit, inactivation gate

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050709	early infantile epileptic encephalopathy	Alliance of Genome Resources
DOID:0060170	generalized epilepsy with febrile seizures plus	Alliance of Genome Resources
DOID:0080422	Dravet syndrome	Alliance of Genome Resources
DOID:0080445	developmental and epileptic encephalopathy 13	Alliance of Genome Resources
DOID:0081118	benign familial infantile seizures 5	Alliance of Genome Resources
DOID:0111294	generalized epilepsy with febrile seizures plus 2	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **132** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Loxodonta africana	100663952		LOXAF19351
Oreochromis niloticus	100703813		ORENI35978
Cavia porcellus	100734003	10141_0:003e2b
Cricetulus griseus	100764200	10029_0:001890	CRIGR23061
Sarcophilus harrisii	100930723		SARHA16916
Pan paniscus	100979577		PANPA09377
Papio anubis	101018366		PAPAN41014
Saimiri boliviensis boliviensis	101037969		SAIBB31294
Felis catus	101096578		FELCA16979
Ovis aries	101113744		SHEEP14304

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OrthoDB (Group)

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Acknowledgements