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Standards Ontologies Notations
sodium voltage-gated channel alpha subunit 8

Summary
Gene Symbol
  • Scn8a
Organism
Rattus norvegicus (Norway rat)
NCBI Gene
29710
PubChem
29710
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Disulfide bond
  • Glycoprotein
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Sodium channel
  • Transmembrane helix
  • Ubl conjugation
  • Voltage-gated channel
Proteins
Displaying 1 entry
UniProt Protein Name
O88420
  • Peripheral nerve protein type 4
  • Sodium channel 6
  • Sodium channel protein type VIII subunit alpha
  • Voltage-gated sodium channel subunit alpha Nav1.6
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 15 in total
GO Term Evidence Code PMID
response to toxic substance
sensory perception of sound
optic nerve development
action potential
sodium ion transport
GO Hierarchy
Displaying all 3 entries
GO Term Evidence Code PMID
protein binding
sodium ion binding
voltage-gated sodium channel activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Rodentia
Group Name
sodium channel protein type 8 subunit alpha
Functional Category
  • G: Carbohydrate transport and metabolism
  • K: Transcription
  • T: Signal transduction mechanisms
Displaying all 8 entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
nervous system process
neuronal action potential
sodium channel activity
sodium ion transmembrane transport
voltage-gated sodium channel activity
Displaying all 9 entries
InterPro
IQ motif, EF-hand binding site
Ion transport domain
Sodium ion transport-associated domain
Voltage gated sodium channel, alpha subunit
Voltage gated sodium channel, alpha-8 subunit
Voltage-dependent channel domain superfamily
Voltage-gated Na+ ion channel, cytoplasmic domain
Voltage-gated cation channel calcium and sodium
Voltage-gated sodium channel alpha subunit, inactivation gate
Disease
Disease Ontology
Displaying all 8 entries
DO ID Disease Name Source
DOID:0050709 early infantile epileptic encephalopathy
DOID:0060170 generalized epilepsy with febrile seizures plus
DOID:0080422 Dravet syndrome
DOID:0080445 developmental and epileptic encephalopathy 13
DOID:0081118 benign familial infantile seizures 5
DOID:0111294 generalized epilepsy with febrile seizures plus 2
DOID:1826 epilepsy
DOID:6000 congestive heart failure
Ortholog
Displaying entries 101 - 110 of 132 in total
Species Gene ID OrthoDB Alliance of Genome Resources Orthologous MAtrix
115165452 SALTR86489
115167796 SALTR75265
115407707 SALFA40534
115491370 TAEGU16505
115584133 SPAAU41739
115584851 SPAAU53038
115618665 STRHB01906
116079929 35658_0:00068d
116436591 CORMO16255
116827806 CHEAB06662
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024