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solute carrier family 8 member A1

Summary

Gene Symbol

Slc8a1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29715

PubChem

29715

Alliance of Genome Resources

RGD:3717

Annotation

Keyword

Alternative splicing
Antiport
Calcium transport
Calmodulin-binding
Cell membrane
Cell projection
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Signal
Sodium transport
Transmembrane helix

Proteins

Displaying **all 9** entries
UniProt	Protein Name
Q01728	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
A0A8L2QNY8	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
A6H9N8	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
A0A8L2QK59	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
A6H9P0	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
A0A8I6AXH4	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
A6H9P6	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
A6H9P2	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
A6H9P3	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 72 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IDA	17267548
embryonic placenta development	ISO
regulation of the force of heart contraction	ISO
regulation of heart rate	ISO
regulation of sodium ion transport	IMP	15774479

GO Hierarchy

biological process

cellular process [inference]

cell communication

cell communication by electrical coupling [inference]

cell communication by electrical coupling involved in cardiac conduction

cell communication involved in cardiac conduction [inference]

cell communication by electrical coupling involved in cardiac conduction

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

cellular developmental process [inference]

cell development [inference]

muscle cell development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to oxygen-containing compound [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic cation import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

vascular associated smooth muscle contraction

striated muscle contraction [inference]

cardiac muscle contraction

relaxation of muscle [inference]

relaxation of smooth muscle

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

post-embryonic development

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

embryonic heart tube development

telencephalon development

tube development [inference]

embryonic heart tube development

cell development [inference]

muscle cell development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

animal organ development [inference]

embryonic organ development [inference]

embryonic placenta development

cellular developmental process [inference]

cell development [inference]

muscle cell development

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

calcium ion homeostasis

intracellular calcium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

calcium ion homeostasis

intracellular calcium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

cellular response to hypoxia

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to hypoxia

response to immobilization stress

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to muscle stretch

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to muscle stretch

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine [inference]

cellular response to caffeine

response to ATP

response to cAMP [inference]

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to caffeine [inference]

cellular response to caffeine

response to ATP

response to cAMP [inference]

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to hydrogen peroxide

response to organophosphorus [inference]

response to ATP

response to cAMP [inference]

cellular response to cAMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to inorganic substance [inference]

response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine [inference]

cellular response to caffeine

response to ATP

response to cAMP [inference]

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to ATP

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

response to salt [inference]

response to ATP

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to cAMP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

calcium ion transport

calcium ion import

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion export

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

inorganic cation import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

organic substance transport [inference]

calcium ion transport

calcium ion import

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion export

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport

regulation of calcium ion transport

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction

positive regulation of the force of heart contraction

regulation of heart rate

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of biological quality [inference]

regulation of the force of heart contraction

positive regulation of the force of heart contraction

regulation of heart rate

positive regulation of cytosolic calcium ion concentration

calcium ion transport into cytosol

negative regulation of cytosolic calcium ion concentration

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

regulation of protein serine/threonine kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein serine/threonine kinase activity

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
microtubule	IDA	16914199
plasma membrane	ISS
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane

plasma membrane

sarcolemma

plasma membrane region [inference]

basolateral plasma membrane

synaptic membrane [inference]

postsynaptic membrane

Z disc

cell junction [inference]

synapse

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

T-tubule

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

dendritic shaft

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

cell periphery

presynapse [inference]

axon terminus

postsynapse

dendritic spine

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
calcium:sodium antiporter activity	ISO
calcium:sodium antiporter activity	IDA	11342562 11916852 19481548 7642578
calcium:sodium antiporter activity	IMP	15774479 17215351 20447431
calcium:sodium antiporter activity	IBA
calcium:sodium antiporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding

ankyrin binding

transmembrane transporter binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SODIUM/CALCIUM EXCHANGER

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion transport
calcium
calmodulin binding
cell communication
metal ion binding
monoatomic ion transport
sodium ion transmembrane transport

Displaying **all 6** entries
InterPro
CalX-like domain superfamily
NCX, central ion-binding domain superfamily
Na-Ca exchanger/integrin-beta4
Sodium/calcium exchanger domain, C-terminal extension
Sodium/calcium exchanger membrane region
Sodium/calcium exchanger protein

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
T-tubule	PMID:11121386
dendritic shaft	PMID:17215351
cell projection	PMID:16914199
microtubule	PMID:16914199
sarcolemma	PMID:11121386
dendritic spine	PMID:16914199

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2316	brain ischemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements