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G protein nucleolar 2

Summary

Gene Symbol

GNL2

Organism

Homo sapiens (human)

External Links

NCBI Gene

29889

PubChem

29889

Alliance of Genome Resources

HGNC:29925

Annotation

Keyword

3D-structure
Acetylation
GTP-binding
Nucleus
Phosphoprotein
Reference proteome
Ribosome biogenesis

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5T0F3
Q13823	Autoantigen NGP-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
biological_process	ND
ribosome biogenesis	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component biogenesis [inference]

ribonucleoprotein complex biogenesis [inference]

ribosome biogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
nucleus	TAS	8822211
nucleolus	IBA IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
GTPase activity	NAS	8822211
RNA binding	HDA	22658674 22681889
GTP binding	NAS	8822211

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Guanine nucleotide-binding protein-like 3-like

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
GTP binding
nucleotide binding

Displaying **all 6** entries
InterPro
Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
GTP binding domain
GTP-binding protein, orthogonal bundle domain superfamily
Nucleolar GTP-binding protein 2, N-terminal domain
Nucleolar GTP-binding protein 2, circularly permuted GTPase motif
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **91 - 92** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Ursus americanus	123782261			URSAM04660
Pongo pygmaeus	129040456	9600_0:0004ad

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024