GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Congenital muscular dystrophy
Cytoplasm
Disease variant
Dystroglycanopathy
GTP-binding
Limb-girdle muscular dystrophy
Nucleotidyltransferase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y5P6	GDP-mannose pyrophosphorylase B GTP-mannose-1-phosphate guanylyltransferase beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein glycosylation	IBA
GDP-mannose biosynthetic process	TAS
GDP-mannose biosynthetic process	IMP	26310427
GDP-mannose biosynthetic process	IBA
GDP-mannose metabolic process	IDA	33986552

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process [inference]

GDP-mannose biosynthetic process from mannose

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process [inference]

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

mannose metabolic process [inference]

GDP-mannose biosynthetic process from mannose

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

GDP-mannose metabolic process

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

GDP-mannose biosynthetic process

GDP-mannose biosynthetic process from mannose

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	23768512
cytoplasm	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mannose-1-phosphate guanylyltransferase (GTP) activity	EXP	33986552
mannose-1-phosphate guanylyltransferase (GTP) activity	IDA	33986552
mannose-1-phosphate guanylyltransferase (GTP) activity	IBA
protein binding	IPI	16189514 25416956 31515488 32296183 33961781 33986552
GTP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

guanylyltransferase activity [inference]

mannose-1-phosphate guanylyltransferase (GTP) activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glucose-1-phosphate adenylyltransferase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
GDP-mannose biosynthetic process
GTP binding
mannose-1-phosphate guanylyltransferase (GTP) activity
nucleotide binding
transferase activity

Displaying **all 4** entries
InterPro
Hexapeptide repeat
Mannose-1-phosphate guanyltransferase, N-terminal domain
Nucleotide-diphospho-sugar transferases
Nucleotidyl transferase domain

Human Protein Atlas

ENSG00000173540

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00966

Name

mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]

References

11082198

Rhea

RHEA:15229

H⁺ + GTP + α-D-mannose 1-phosphate

diphosphate + GDP-α-D-mannose

Enzyme

2.7.7.13

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0110294	autosomal recessive limb-girdle muscular dystrophy type 2T	Alliance of Genome Resources
DOID:0111233	congenital muscular dystrophy-dystroglycanopathy type A14	Alliance of Genome Resources
DOID:0112374	muscular dystrophy-dystroglycanopathy	Alliance of Genome Resources
DOID:0112377	muscular dystrophy-dystroglycanopathy type B14	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of **142** in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000054	Micropenis
HP:0000158	Macroglossia
HP:0000175	Cleft palate
HP:0000218	High palate
HP:0000238	Hydrocephalus
HP:0000252	Microcephaly
HP:0000407	Sensorineural hearing impairment
HP:0000467	Neck muscle weakness

Displaying **all 8** entries
Disease ID	Disease Name
OMIM:615352	autosomal recessive limb-girdle muscular dystrophy type 2T
OMIM:615351	muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14
OMIM:615350	muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A14
ORPHA:588	muscle-eye-brain disease muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1
ORPHA:363623	autosomal recessive limb-girdle muscular dystrophy type 2T
ORPHA:353327	obsolete congenital myasthenic syndromes with glycosylation defect
ORPHA:370959	muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2 muscular dystrophy-dystroglycanopathy type B5 obsolete congenital muscular dystrophy with cerebellar involvement
ORPHA:370968	congenital muscular dystrophy with intellectual disability muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2 muscular dystrophy-dystroglycanopathy type B5 muscular dystrophy-dystroglycanopathy type B6

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	29925	Xenbase:XB-GENE-922650
Xenopus tropicalis	40599	Xenbase:XB-GENE-922650
Mus musculus	331026	Xenbase:XB-GENE-922650	MOUSE61930
Danio rerio	445097		DANRE22403
Pan troglodytes	460378		PANTR31162
Bos taurus	514161		BOVIN17824
Macaca mulatta	705454		MACMU29533
Monodelphis domestica	100028039		MONDO30686
Callithrix jacchus	100397938		CALJA11912
Pongo abelii	100436355		PONAB25882

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements