GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Congenital muscular dystrophy
Dystroglycanopathy
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Limb-girdle muscular dystrophy
Lissencephaly
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UKY4	Dolichyl-phosphate-mannose--protein mannosyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
positive regulation of protein O-linked glycosylation	IEA
reactive gliosis	IEA
basement membrane organization	IEA
dentate gyrus development	IEA
protein O-linked mannosylation	IBA IMP	28512129

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

mannosylation [inference]

protein mannosylation [inference]

protein O-linked mannosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

developmental process [inference]

anatomical structure development [inference]

dentate gyrus development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

neuroinflammatory response [inference]

reactive gliosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
cytosol	IDA
endoplasmic reticulum membrane	TAS
nucleolus	IDA
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
dolichyl-phosphate-mannose-protein mannosyltransferase activity	IBA
mannosyltransferase activity	IMP	28512129
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity

dolichyl-phosphate-mannose-protein mannosyltransferase activity

catalytic activity, acting on a protein [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000009830

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg139

Gene Symbol

POMT2

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	XP_345709	XM_345709
Drosophila melanogaster	NP_569858	NM_130502
Caenorhabditis elegans	NP_491320	NM_058919
Mus musculus	NP_700464	NM_153415

KEGG BRITE Database

Orthology

K00728

Name

dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R07620	2.4.1.109	G74840NI	G61491DK

Disease

Disease Ontology

Displaying entries **131 - 140** of **164** in total

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DO ID	Disease Name	Source
DOID:13934	facial paralysis	DisGeNET
DOID:14159	obstructive hydrocephalus	DisGeNET
DOID:1432	blindness	DisGeNET DisGeNET
DOID:14323	Marfan syndrome	DisGeNET
DOID:14524	senile degeneration of brain	DisGeNET
DOID:14686	Axenfeld-Rieger syndrome	DisGeNET
DOID:14766	renal agenesis	DisGeNET
DOID:1573	communicating hydrocephalus	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:1686	glaucoma	DisGeNET

The Human Phenotype Ontology

Displaying entries **101 - 110** of **175** in total

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HPO ID	HPO Term
HP:0002365	Hypoplasia of the brainstem
HP:0002435	Meningocele
HP:0002438	Cerebellar malformation
HP:0002465	Poor speech
HP:0002505	Loss of ambulation
HP:0002518	Abnormal periventricular white matter morphology
HP:0002536	Abnormal cortical gyration
HP:0002540	Inability to walk
HP:0002650	Scoliosis
HP:0002803	Congenital contracture

Displaying **all 9** entries
Disease ID	Disease Name
OMIM:613150	muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2
ORPHA:899	muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 7 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A13 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A5 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A6 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A9 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 11 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 12 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 8 muscular dystrophy-dystroglycanopathy, type A
ORPHA:370968	congenital muscular dystrophy with intellectual disability muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2 muscular dystrophy-dystroglycanopathy type B5 muscular dystrophy-dystroglycanopathy type B6
OMIM:613156	muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2
OMIM:613158	autosomal recessive limb-girdle muscular dystrophy type 2N
OMIM:236670	muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1
ORPHA:370959	muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2 muscular dystrophy-dystroglycanopathy type B5 obsolete congenital muscular dystrophy with cerebellar involvement
ORPHA:588	muscle-eye-brain disease muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1
ORPHA:206559	autosomal recessive limb-girdle muscular dystrophy type 2N

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **21 - 30** of 74 in total

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Species	Gene ID	Orthologous MAtrix
Pan paniscus	100991424	PANPA12418
Pan troglodytes	453067	PANTR09235
Pongo abelii	100437813	PONAB07564
Canis lupus familiaris	480400	CANLF18120
Vulpes vulpes	112918304	VULVU10757
Ursus americanus	123798945	URSAM00905
Ailuropoda melanoleuca	100465937	AILME05426
Mustela putorius furo	101671153	MUSPF19303
Felis catus	101085294	FELCA13605
Felis catus	101101141	FELCA13605

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements