GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Congenital muscular dystrophy
Dystroglycanopathy
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Limb-girdle muscular dystrophy
Lissencephaly
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UKY4	Dolichyl-phosphate-mannose--protein mannosyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
positive regulation of protein O-linked glycosylation	IEA
reactive gliosis	IEA
basement membrane organization	IEA
dentate gyrus development	IEA
protein O-linked mannosylation	IBA IMP	28512129

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

mannosylation [inference]

protein mannosylation [inference]

protein O-linked mannosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

developmental process [inference]

anatomical structure development [inference]

dentate gyrus development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

neuroinflammatory response [inference]

reactive gliosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of glycoprotein metabolic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of glycoprotein biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein glycosylation [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

regulation of protein O-linked glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of glycoprotein biosynthetic process [inference]

positive regulation of protein glycosylation [inference]

positive regulation of protein O-linked glycosylation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
cytosol	IDA
endoplasmic reticulum membrane	TAS
nucleolus	IDA
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
dolichyl-phosphate-mannose-protein mannosyltransferase activity	IBA
mannosyltransferase activity	IMP	28512129
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity

dolichyl-phosphate-mannose-protein mannosyltransferase activity

catalytic activity, acting on a protein [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000009830

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg139

Gene Symbol

POMT2

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	XP_345709	XM_345709
Drosophila melanogaster	NP_569858	NM_130502
Caenorhabditis elegans	NP_491320	NM_058919
Mus musculus	NP_700464	NM_153415

KEGG BRITE Database

Orthology

K00728

Name

dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R07620	2.4.1.109	G74840NI	G61491DK

Disease

Disease Ontology

Displaying entries **81 - 90** of **164** in total

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DO ID	Disease Name	Source
DOID:0110444	dilated cardiomyopathy 1X	DisGeNET
DOID:0110445	dilated cardiomyopathy 1KK	DisGeNET
DOID:0110446	dilated cardiomyopathy 1W	DisGeNET
DOID:0110447	dilated cardiomyopathy 1DD	DisGeNET
DOID:0110448	dilated cardiomyopathy 1HH	DisGeNET
DOID:0110449	dilated cardiomyopathy 1M	DisGeNET
DOID:0110450	dilated cardiomyopathy 1II	DisGeNET
DOID:0110451	dilated cardiomyopathy 1O	DisGeNET
DOID:0110452	dilated cardiomyopathy 1T	DisGeNET
DOID:0110453	dilated cardiomyopathy 1EE	DisGeNET

The Human Phenotype Ontology

Displaying entries **131 - 140** of **175** in total

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HPO ID	HPO Term
HP:0003691	Scapular winging
HP:0003697	Scapuloperoneal amyotrophy
HP:0003701	Proximal muscle weakness
HP:0003707	Calf muscle pseudohypertrophy
HP:0003712	Skeletal muscle hypertrophy
HP:0004374	Hemiplegia/hemiparesis
HP:0004637	Decreased cervical spine mobility
HP:0006785	Limb-girdle muscular dystrophy
HP:0006829	Severe muscular hypotonia
HP:0006888	Meningoencephalocele

Displaying **all 9** entries
Disease ID	Disease Name
OMIM:613150	muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2
ORPHA:899	muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 7 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A13 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A5 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A6 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A9 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 11 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 12 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 8 muscular dystrophy-dystroglycanopathy, type A
ORPHA:370968	congenital muscular dystrophy with intellectual disability muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2 muscular dystrophy-dystroglycanopathy type B5 muscular dystrophy-dystroglycanopathy type B6
OMIM:613156	muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2
OMIM:613158	autosomal recessive limb-girdle muscular dystrophy type 2N
OMIM:236670	muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1
ORPHA:370959	muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14 muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B2 muscular dystrophy-dystroglycanopathy type B5 obsolete congenital muscular dystrophy with cerebellar involvement
ORPHA:588	muscle-eye-brain disease muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1
ORPHA:206559	autosomal recessive limb-girdle muscular dystrophy type 2N

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **71 - 74** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	853113	SGD:S000003431
Saccharomyces cerevisiae S288C	854499	SGD:S000005848
Nannospalax galili	103739582		NANGA08847
Carlito syrichta	103259401		CARSF16833

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements