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granzyme A

Summary

Gene Symbol

GZMA

Organism

Homo sapiens (human)

External Links

NCBI Gene

3001

PubChem

3001

Alliance of Genome Resources

HGNC:4708

Annotation

Keyword

3D-structure
Alternative promoter usage
Cytolysis
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P12544	CTL tryptase Cytotoxic T-lymphocyte proteinase 1 Fragmentin-1 Granzyme-1 Hanukkah factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
pyroptosis	IDA	32299851
response to bacterium	IEA
killing of cells of another organism	IEA
cytotoxic T cell pyroptotic process	IDA	32299851
granzyme-mediated programmed cell death signaling pathway	IBA IDA	32299851 34022140

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process

protein maturation

cellular process [inference]

cell killing [inference]

killing of cells of another organism

signal transduction [inference]

granzyme-mediated programmed cell death signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

pyroptosis

cytotoxic T cell pyroptotic process

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of nuclease activity [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of cellular process [inference]

signal transduction [inference]

granzyme-mediated programmed cell death signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of DNA metabolic process [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of DNA metabolic process [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of oxidoreductase activity

negative regulation of binding [inference]

negative regulation of DNA binding

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of oxidoreductase activity

regulation of hydrolase activity [inference]

regulation of nuclease activity [inference]

regulation of deoxyribonuclease activity [inference]

regulation of endodeoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity [inference]

negative regulation of deoxyribonuclease activity [inference]

negative regulation of endodeoxyribonuclease activity

regulation of oxidoreductase activity [inference]

negative regulation of oxidoreductase activity

regulation of binding [inference]

negative regulation of binding [inference]

negative regulation of DNA binding

regulation of DNA binding [inference]

negative regulation of DNA binding

Displaying **all 4** entries
GO Term	Evidence Code	PMID
immunological synapse	TAS	12524539
extracellular space	IBA IEA
nucleus	TAS	11909973
cytoplasm	IDA	20038786 34022140

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12524539
protein homodimerization activity	IDA	12819770
serine-type endopeptidase activity	IBA IDA	11331782 12819770 32299851 34022140 36899106

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serine protease

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 5** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14938		MGI:109266	MOUSE11576
Rattus norvegicus	266708		RGD:628640	RATNO24138
Xenopus laevis	379554		Xenbase:XB-GENE-864904
Pan troglodytes	461873	9598_0:0018d2		PANTR35564
Canis lupus familiaris	487207			CANLF06695
Xenopus laevis	494696		Xenbase:XB-GENE-17331772
Bos taurus	539093			BOVIN15935
Macaca mulatta	705712			MACMU39564
Danio rerio	795070		ZFIN:ZDB-GENE-091204-156
Monodelphis domestica	100031794			MONDO16601

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements