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KIT proto-oncogene, receptor tyrosine kinase a

Summary

Gene Symbol

kita

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

30256

PubChem

30256

Alliance of Genome Resources

ZFIN:ZDB-GENE-980526-464

Annotation

Keyword

ATP-binding
Cell membrane
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Magnesium
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8JFR5	Tyrosine-protein kinase Kit
A0A8M3ALF9
B3DGS5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
hematopoietic progenitor cell differentiation	IBA
protein phosphorylation	IEA
transmembrane receptor protein tyrosine kinase signaling pathway	IEA
positive regulation of cell population proliferation	IBA
gastro-intestinal system smooth muscle contraction	IMP	23297728

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

Kit signaling pathway

cytokine-mediated signaling pathway [inference]

Kit signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

melanocyte apoptotic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

cellular developmental process [inference]

cell differentiation

hematopoietic progenitor cell differentiation

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

pigment cell differentiation [inference]

melanocyte differentiation

cell fate commitment [inference]

stem cell fate commitment

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

melanocyte migration

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction [inference]

gastro-intestinal system smooth muscle contraction

developmental process [inference]

cellular developmental process [inference]

cell differentiation

hematopoietic progenitor cell differentiation

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

pigment cell differentiation [inference]

melanocyte differentiation

cell fate commitment [inference]

stem cell fate commitment

pigmentation

developmental pigmentation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

Kit signaling pathway

cytokine-mediated signaling pathway [inference]

Kit signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
plasma membrane	IEA
membrane	IEA
receptor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
protein kinase activity	IEA
protein tyrosine kinase activity	IEA
transmembrane receptor protein tyrosine kinase activity	IBA
transmembrane receptor protein tyrosine kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

ephrin receptor activity [inference]

platelet-derived growth factor receptor activity [inference]

collagen receptor activity [inference]

protein tyrosine kinase collagen receptor activity

neurotrophin receptor activity [inference]

brain-derived neurotrophic factor receptor activity

protein-hormone receptor activity [inference]

insulin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vascular endothelial growth factor receptor

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
growth factor binding
metal ion binding
nucleotide binding
positive regulation of cell migration
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying entries **1 - 10** of 11 in total

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InterPro
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, active site
Tyrosine-protein kinase, catalytic domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
axon	PMID:25490391

Ortholog

Displaying entries **1 - 10** of **105** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	2321	WB:WBGene00006894
Caenorhabditis elegans	2322	WB:WBGene00006894
Caenorhabditis elegans	2324	WB:WBGene00006894
Caenorhabditis elegans	3791	WB:WBGene00006894
Homo sapiens	3815	HGNC:6342	HUMAN75595
Caenorhabditis elegans	5156	WB:WBGene00006894
Caenorhabditis elegans	12978	WB:WBGene00006894
Caenorhabditis elegans	14254	WB:WBGene00006894
Caenorhabditis elegans	14255	WB:WBGene00006894
Caenorhabditis elegans	14257	WB:WBGene00006894

GlyTouCan

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Annotation

OrthoDB (Group)

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Acknowledgements