GlyCosmos Portal

Displaying **all 5** entries
GO Term	Evidence Code	PMID
3-hydroxyacyl-CoA dehydrogenase activity	IDA	11489939
3-hydroxyacyl-CoA dehydrogenase activity	IBA
transferase activity	IEA
identical protein binding	IDA	10231530
NAD+ binding	IDA	10840044

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-hydroxyacyl-CoA dehydrogenase activity

transferase activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

ion binding [inference]

anion binding [inference]

NAD+ binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism

Displaying **all 4** entries
Gene Ontology
NAD+ binding
fatty acid metabolic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 5** entries
InterPro
3-hydroxyacyl-CoA dehydrogenase, C-terminal
3-hydroxyacyl-CoA dehydrogenase, NAD binding
6-phosphogluconate dehydrogenase, domain 2
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
NAD(P)-binding domain superfamily

Human Protein Atlas

ENSG00000138796

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00022

Name

3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]

References

Rhea

RHEA:22432

a (3S)-3-hydroxyacyl-CoA + NAD⁺

H⁺ + NADH + a 3-oxoacyl-CoA

Enzyme

1.1.1.35

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070215	familial hyperinsulinemic hypoglycemia 4	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 43 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000580	Pigmentary retinopathy
HP:0000825	Hyperinsulinemic hypoglycemia
HP:0001249	Intellectual disability
HP:0001252	Hypotonia
HP:0001254	Lethargy
HP:0001270	Motor delay
HP:0001289	Confusion
HP:0001290	Generalized hypotonia
HP:0001319	Neonatal hypotonia

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:231530	3-hydroxyacyl-CoA dehydrogenase deficiency
ORPHA:71212	hyperinsulinemic hypoglycemia, familial, 4
OMIM:609975	hyperinsulinemic hypoglycemia, familial, 4

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002407
Gene Name: hydroxyacyl-CoA dehydrogenase

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3033	Xenbase:XB-GENE-1007278
Mus musculus	15107		MOUSE37646
Rattus norvegicus	113965	Xenbase:XB-GENE-1007278	RATNO23566
Sus scrofa	397604		PIGXX34305
Danio rerio	445121		DANRE17161
Pan troglodytes	461424		PANTR34281
Bos taurus	532785		BOVIN31091
Macaca mulatta	696181		MACMU37192
Monodelphis domestica	100010946		MONDO26053
Ornithorhynchus anatinus	100080904		ORNAN03621

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements