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hemoglobin subunit alpha 1

Summary

Gene Symbol

HBA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3039

PubChem

3039

Alliance of Genome Resources

HGNC:4823

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disease variant
Glycation
Heme
Hereditary hemolytic anemia
Oxygen transport
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P69905	Alpha-globin Hemoglobin alpha chain
D1MGQ2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
nitric oxide transport	IDA	8292032
response to hydrogen peroxide	IDA	19740759
hydrogen peroxide catabolic process	IBA IDA	19740759
cellular oxidant detoxification	IEA
oxygen transport	IDA IMP NAS TAS	11159543 11307949 7518430 881729

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular detoxification [inference]

cellular oxidant detoxification

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to chemical [inference]

response to organic substance [inference]

response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

localization [inference]

establishment of localization [inference]

transport [inference]

gas transport [inference]

organic substance transport [inference]

one-carbon compound transport [inference]

carbon dioxide transport

nitrogen compound transport [inference]

nitric oxide transport

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

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GO Term	Evidence Code	PMID
haptoglobin-hemoglobin complex	IBA IDA	19740759
membrane	HDA	19946888
endocytic vesicle lumen	TAS
extracellular region	TAS
blood microparticle	HDA	22516433

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endocytic vesicle lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

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GO Term	Evidence Code	PMID
protein binding	IPI	10390349 10930828 11159543 11724557 12072504 1552945 15550245 15835899 16169070 23123858 25156257 25416956 28665412 29997244 30833564 32296183 37398436 6683087 9441940 9830011 9894000
G protein-coupled receptor binding	IDA	18077343
oxygen binding	IBA
haptoglobin binding	IBA IDA	19740759
oxygen carrier activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding

haptoglobin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

molecular carrier activity [inference]

oxygen carrier activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hemoglobin subunit alpha

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
haptoglobin binding
heme binding
hydrogen peroxide catabolic process
iron ion binding
organic acid binding
oxygen binding
oxygen transport

Displaying **all 5** entries
InterPro
Globin-like superfamily
Globin/Protoglobin
Globin
Hemoglobin, alpha-type
Hemoglobin, pi

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0110031	hemoglobin H disease	Alliance of Genome Resources
DOID:0111363	Heinz body anemia	Alliance of Genome Resources
DOID:0111631	familial erythrocytosis 7	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1099	alpha thalassemia	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15122	MGI:96015	MOUSE03865
Rattus norvegicus	25632	RGD:2782
Danio rerio	30507	ZFIN:ZDB-GENE-980526-79
Drosophila melanogaster	41930	FB:FBgn0027657
Mus musculus	110257	MGI:96016	MOUSE03865
Rattus norvegicus	287167	RGD:1359209	RATNO02147
Rattus norvegicus	360504	RGD:1359364
Xenopus tropicalis	394454	Xenbase:XB-GENE-478141
Xenopus laevis	397869	Xenbase:XB-GENE-865144
Bos taurus	512439		BOVIN19908

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements