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hemoglobin subunit alpha 1

Summary

Gene Symbol

HBA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3039

PubChem

3039

Alliance of Genome Resources

HGNC:4823

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Disease variant
Glycation
Heme
Hereditary hemolytic anemia
Oxygen transport
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P69905	Alpha-globin Hemoglobin alpha chain
D1MGQ2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nitric oxide transport	IDA	8292032
response to hydrogen peroxide	IDA	19740759
hydrogen peroxide catabolic process	IBA IDA	19740759
cellular oxidant detoxification	IEA
oxygen transport	IDA IMP NAS TAS	11159543 11307949 7518430 881729

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular detoxification [inference]

cellular oxidant detoxification

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to chemical [inference]

response to organic substance [inference]

response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

localization [inference]

establishment of localization [inference]

transport [inference]

gas transport [inference]

organic substance transport [inference]

one-carbon compound transport [inference]

carbon dioxide transport

nitrogen compound transport [inference]

nitric oxide transport

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	21805676
cytosol	TAS
hemoglobin complex	IBA IDA IPI TAS	15449937 16765986 19740759 7555018 881729 9665850
extracellular exosome	HDA	20458337 23533145

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endocytic vesicle lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
peroxidase activity	IBA IDA	19740759
organic acid binding	IBA
iron ion binding	IEA
heme binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding

haptoglobin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

molecular carrier activity [inference]

oxygen carrier activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hemoglobin subunit alpha

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
haptoglobin binding
heme binding
hydrogen peroxide catabolic process
iron ion binding
organic acid binding
oxygen binding
oxygen transport

Displaying **all 5** entries
InterPro
Globin-like superfamily
Globin/Protoglobin
Globin
Hemoglobin, alpha-type
Hemoglobin, pi

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0110031	hemoglobin H disease	Alliance of Genome Resources
DOID:0111363	Heinz body anemia	Alliance of Genome Resources
DOID:0111631	familial erythrocytosis 7	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1099	alpha thalassemia	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Microcebus murinus	105856255			MICMU08150
Equus asinus asinus	106836157			EQUAS27970
Xenopus laevis	108702027		Xenbase:XB-GENE-17345270
Sus scrofa	110259958			PIGXX21293
Pongo abelii	112128473	9601_0:003da1
Vulpes vulpes	112909065			VULVU35099
Pseudonaja textilis	113445722			PSETE18719
Athene cunicularia	113485608			ATHCN15373
Cricetulus griseus	113836649			CRIGR08780
Cricetulus griseus	113836650			CRIGR08780

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements