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hypocretin receptor 2

Summary

Gene Symbol

HCRTR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3062

PubChem

3062

Alliance of Genome Resources

HGNC:4849

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
S4X0W3	Hypocretin receptor type 2
O43614	Hypocretin receptor type 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
neuropeptide signaling pathway	IDA	26950369
neuropeptide signaling pathway	IBA
chemical synaptic transmission	TAS	9491897
feeding behavior	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

multicellular organismal process [inference]

behavior [inference]

rhythmic behavior [inference]

circadian behavior [inference]

circadian sleep/wake cycle process

feeding behavior

locomotion

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

rhythmic process [inference]

circadian rhythm [inference]

circadian behavior [inference]

circadian sleep/wake cycle process

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of circadian rhythm [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, wakefulness

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, wakefulness

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA
plasma membrane	TAS
plasma membrane	IDA	26950369
plasma membrane	IBA
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

cell junction [inference]

synapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	32814053
neuropeptide receptor activity	TAS	9491897
orexin receptor activity	IDA	26950369
orexin receptor activity	IBA
peptide hormone binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Neuropeptide CCHamide-1 receptor

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	3061	WB:WBGene00012275
Xenopus tropicalis	3062	Xenbase:XB-GENE-952341
Caenorhabditis elegans	25593	WB:WBGene00012275
Rattus norvegicus	25605	Xenbase:XB-GENE-952341	RATNO41214
Caenorhabditis elegans	230777	WB:WBGene00012275
Mus musculus	387285	Xenbase:XB-GENE-952341	MOUSE60562
Sus scrofa	397428		PIGXX31315
Canis lupus familiaris	399545		CANLF02870
Pan troglodytes	462786		PANTR38432
Bos taurus	529603		BOVIN18219

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OrthoDB (Group)

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Acknowledgements