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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
huntingtin
Summary
- Gene Symbol
-
- HTT
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Apoptosis
- Cytoplasm
- Cytoplasmic vesicle
- Disease variant
- Endosome
- Intellectual disability
- Myristate
- Neurodegeneration
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Triplet repeat expansion
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P42858 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | ||
| Golgi organization | ||
| vocal learning | ||
| positive regulation of mitophagy | ||
| regulation of cAMP-dependent protein kinase activity |
GO Hierarchy
biological process
cellular process [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of transport [inference]
regulation of transmembrane transport [inference]
regulation of transmembrane transporter activity [inference]
positive regulation of transmembrane transport [inference]
regulation of monoatomic ion transmembrane transport [inference]
regulation of monoatomic ion transport [inference]
regulation of metal ion transport [inference]
regulation of monoatomic ion transmembrane transport [inference]
positive regulation of monoatomic ion transport [inference]
positive regulation of transport [inference]
positive regulation of biological process [inference]
positive regulation of cellular process [inference]
positive regulation of transport [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of transmembrane transport [inference]
regulation of transmembrane transporter activity [inference]
positive regulation of transmembrane transport [inference]
regulation of monoatomic ion transmembrane transport [inference]
positive regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| early endosome | ||
| Golgi apparatus | ||
| late endosome | ||
| cytoplasmic vesicle membrane | ||
| protein-containing complex |
| GO Term | Evidence Code | PMID |
|---|---|---|
| kinase binding | ||
| protein binding |
|
|
| dynein intermediate chain binding | ||
| heat shock protein binding | ||
| dynactin binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Huntingtin
- Functional Category
-
- P: Inorganic ion transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| microtubule-based transport |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12858 | Huntington's disease | |
| DOID:1289 | neurodegenerative disease | |
| DOID:14330 | Parkinson's disease | |
| DOID:224 | transient cerebral ischemia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 15194 | MGI:96067 | MOUSE44169 | ||
| 29424 | RGD:68337 | RATNO08050 | ||
| 30214 | ZFIN:ZDB-GENE-990415-131 | DANRE17460 | ||
| 43392 | FB:FBgn0027655 | |||
| 397014 | PIGXX33226 | |||
| 461084 | 9598_0:0013ee | PANTR33200 | ||
| 479074 | CANLF12167 | |||
| 493287 | Xenbase:XB-GENE-1013462 | |||
| 615059 | BOVIN31928 | |||
| 100015315 | MONDO27021 |
