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complement factor H

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

3075

PubChem

3075

Alliance of Genome Resources

HGNC:4883

Annotation

Keyword

3D-structure
Age-related macular degeneration
Alternative splicing
Complement alternate pathway
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hemolytic uremic syndrome
Host-virus interaction
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Sulfation
Sushi

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0D9SG88
P08603	H factor 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
proteolysis	IDA	28671664
complement activation, alternative pathway	IEA
regulation of complement activation	IDA	25284781
regulation of complement-dependent cytotoxicity	IDA	25284781
regulation of complement activation, alternative pathway	IDA	20378178 28671664

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, alternative pathway

activation of immune response [inference]

complement activation

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune effector process [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of complement-dependent cytotoxicity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
serine-type endopeptidase complex	IPI	28671664
blood microparticle	HDA	22516433
symbiont cell surface	IDA	23332154
extracellular space	IBA NAS	20378178 28671664

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

serine-type peptidase complex [inference]

serine-type endopeptidase complex

endopeptidase complex [inference]

serine-type endopeptidase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

symbiont cell surface

blood microparticle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16612335 17244159 17293598 17339482 17399790 18627465 18786923 19050261 19084272 19225461 19632990 19680263 19850925 20042240 21317894 21930971 21979047 22786770 23332154 24835392 26468283 26538390 28258151 28533443 28671664 29374201
heparin binding	IDA	22471560
heparan sulfate proteoglycan binding	IDA	22471560
complement component C3b binding	IBA
identical protein binding	IPI	19505476 19850925 26468283

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

identical protein binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement factor H

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
complement activation
complement component C3b binding

Displaying **all 2** entries
InterPro
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily

Disease

Disease Ontology

Displaying entries **1 - 10** of 27 in total

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DO ID	Disease Name	Source
DOID:0060746	basal laminar drusen	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0080301	atypical hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0110017	age related macular degeneration 4	Alliance of Genome Resources
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:12030	panuveitis	Alliance of Genome Resources
DOID:12554	hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:12574	posterior uveitis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 40 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12628		MGI:88385	MOUSE30483
Rattus norvegicus	155012		RGD:620428	RATNO06818
Mus musculus	214403		MGI:3646434	MOUSE30453
Bos taurus	280816			BOVIN07980
Xenopus laevis	379371		Xenbase:XB-GENE-981268
Xenopus tropicalis	394826		Xenbase:XB-GENE-981265
Sus scrofa	397525			PIGXX38620
Pan troglodytes	457601	9598_0:0003d5
Canis lupus familiaris	478952			CANLF14329
Danio rerio	492777		ZFIN:ZDB-GENE-041114-123

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements