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Guidelines

MIRAGE

homogentisate 1,2-dioxygenase

Summary

Gene Symbol

HGD

Organism

Homo sapiens (human)

External Links

NCBI Gene

3081

PubChem

3081

Alliance of Genome Resources

HGNC:4892

Annotation

Keyword

3D-structure
Acetylation
Dioxygenase
Disease variant
Iron
Metal-binding
Phenylalanine catabolism
Proteomics identification
Reference proteome
Tyrosine catabolism

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q93099	Homogentisate oxygenase Homogentisic acid oxidase Homogentisicase
B3KW64	Homogentisate oxygenase Homogentisic acid oxidase Homogentisicase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
L-phenylalanine catabolic process	IBA
L-phenylalanine catabolic process	IEA
tyrosine catabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic cyclic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic cyclic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

organic cyclic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic cyclic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
homogentisate 1,2-dioxygenase activity	IMP	8782815
homogentisate 1,2-dioxygenase activity	IBA
protein binding	IPI	21044950 32296183
identical protein binding	IPI	25416956 32296183
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

homogentisate 1,2-dioxygenase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

homogentisate 1,2-dioxygenase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Homogentisate 1,2-dioxygenase 2

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
L-phenylalanine catabolic process
dioxygenase activity
homogentisate 1,2-dioxygenase activity
metal ion binding
oxidoreductase activity
tyrosine metabolic process

Displaying **all 5** entries
InterPro
Homogentisate 1,2-dioxygenase, C-terminal domain
Homogentisate 1,2-dioxygenase, N-terminal domain
Homogentisate 1,2-dioxygenase
RmlC-like cupin domain superfamily
RmlC-like jelly roll fold

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9270	alkaptonuria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

1

2

3

4

5

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Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3081	Xenbase:XB-GENE-996013
Mus musculus	15233		MOUSE17483
Rattus norvegicus	360719		RATNO03681
Pan troglodytes	460613		PANTR31939
Canis lupus familiaris	478578		CANLF13337
Bos taurus	507496		BOVIN14575
Macaca mulatta	713499		MACMU28750
Monodelphis domestica	100017306		MONDO21294
Equus caballus	100060993		HORSE14384
Pongo abelii	100171592		PONAB25998

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Last updated: December 8, 2025