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homogentisate 1,2-dioxygenase

Summary

Gene Symbol

HGD

Organism

Homo sapiens (human)

External Links

NCBI Gene

3081

PubChem

3081

Alliance of Genome Resources

HGNC:4892

Annotation

Keyword

3D-structure
Acetylation
Dioxygenase
Disease variant
Iron
Metal-binding
Phenylalanine catabolism
Reference proteome
Tyrosine catabolism

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B3KW64	Homogentisate oxygenase Homogentisic acid oxidase Homogentisicase
Q93099	Homogentisate oxygenase Homogentisic acid oxidase Homogentisicase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
tyrosine catabolic process	IEA
L-phenylalanine catabolic process	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic cyclic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic cyclic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

organic cyclic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

organic cyclic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

tyrosine catabolic process

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-phenylalanine metabolic process [inference]

L-phenylalanine catabolic process

tyrosine metabolic process [inference]

tyrosine catabolic process

aromatic amino acid family catabolic process [inference]

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic amino acid family catabolic process [inference]

alpha-amino acid catabolic process [inference]

tyrosine catabolic process

erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [inference]

L-phenylalanine catabolic process

aromatic compound catabolic process [inference]

aromatic amino acid family catabolic process [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21044950 32296183
metal ion binding	IEA
identical protein binding	IPI	25416956 32296183
homogentisate 1,2-dioxygenase activity	IBA IMP	8782815

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

homogentisate 1,2-dioxygenase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

homogentisate 1,2-dioxygenase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Homogentisate 1,2-dioxygenase 1

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
L-phenylalanine catabolic process
dioxygenase activity
homogentisate 1,2-dioxygenase activity
metal ion binding
oxidoreductase activity
tyrosine metabolic process

Displaying **all 5** entries
InterPro
Homogentisate 1,2-dioxygenase, C-terminal domain
Homogentisate 1,2-dioxygenase, N-terminal domain
Homogentisate 1,2-dioxygenase
RmlC-like cupin domain superfamily
RmlC-like jelly roll fold

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9270	alkaptonuria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 82 in total

1

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5

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Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15233		MGI:96078	MOUSE17483
Drosophila melanogaster	34552		FB:FBgn0040211
Caenorhabditis elegans	172726		WB:WBGene00001843
Danio rerio	259189		ZFIN:ZDB-GENE-020802-5
Rattus norvegicus	360719		RGD:1308757	RATNO03681
Xenopus laevis	447328		Xenbase:XB-GENE-996016
Pan troglodytes	460613	9598_0:0010c9		PANTR31939
Canis lupus familiaris	478578			CANLF13337
Bos taurus	507496			BOVIN14575
Macaca mulatta	713499			MACMU28750

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Last updated: December 9, 2024