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integrin subunit beta 6

Summary

Gene Symbol

Itgb6

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

311061

PubChem

311061

Alliance of Genome Resources

RGD:1303119

Annotation

Keyword

Calcium
Cell adhesion
Cell junction
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Integrin
Magnesium
Metal-binding
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6AYF4
A6HLT3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 25 in total

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GO Term	Evidence Code	PMID
cell migration	IBA
transforming growth factor beta production	ISO
bronchiole development	ISO
phospholipid homeostasis	ISO
surfactant homeostasis	ISO

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cytokine production [inference]

transforming growth factor beta production

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

mononuclear cell differentiation [inference]

dendritic cell differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

cell motility [inference]

cell migration

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

myeloid dendritic cell activation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

cytokine production [inference]

transforming growth factor beta production

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

tooth mineralization [inference]

enamel mineralization

tube development [inference]

respiratory tube development [inference]

bronchiole development

lung alveolus development

animal organ development [inference]

respiratory tube development [inference]

bronchiole development

hard palate development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

mononuclear cell differentiation [inference]

dendritic cell differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

myeloid dendritic cell differentiation [inference]

Langerhans cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

chemical homeostasis [inference]

lipid homeostasis [inference]

phospholipid homeostasis

multicellular organismal-level chemical homeostasis [inference]

surfactant homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to wounding

wound healing

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

cellular response to ionizing radiation

cellular response to radiation [inference]

cellular response to ionizing radiation

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	ISO
cell junction	ISO
focal adhesion	IBA ISO ISS
integrin alphav-beta6 complex	IBA ISO ISS
receptor complex	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

integrin complex [inference]

integrin alphav-beta6 complex

protein complex involved in cell adhesion [inference]

integrin complex [inference]

integrin alphav-beta6 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex [inference]

integrin alphav-beta6 complex

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome

cell surface

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
integrin binding	IBA ISO
metal ion binding	IEA
molecular function activator activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

molecular function regulator activity [inference]

molecular function activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Integrin beta subunit

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cell adhesion mediated by integrin
cell migration
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

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InterPro
EGF-like domain, extracellular
Integrin beta N-terminal
Integrin beta subunit, VWA domain
Integrin beta subunit, cytoplasmic domain
Integrin beta subunit, tail
Integrin beta subunit
Integrin beta tail domain superfamily
Integrin beta, epidermal growth factor-like domain 1
Integrin domain superfamily
PSI domain

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0110064	amelogenesis imperfecta type 1H	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:9675	pulmonary emphysema	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 80** of **132** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Microcebus murinus	105860472			MICMU13795
Dipodomys ordii	105996530	10020_0:0005b9		DIPOR00725
Salmo salar	106574237			SALSA47589
Equus asinus asinus	106843040			EQUAS02009
Cyprinodon variegatus	107082545			CYPVA04441
Marmota marmota marmota	107136880	9994_0:002655
Sinocyclocheilus grahami	107564862			SINGR04251
Sinocyclocheilus grahami	107597145			SINGR49361
Kryptolebias marmoratus	108228229			KRYMA28934
Ictalurus punctatus	108270759			ICTPU01756

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024