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major histocompatibility complex, class II, DO beta

Summary

Gene Symbol

HLA-DOB

Organism

Homo sapiens (human)

External Links

NCBI Gene

3112

PubChem

3112

Alliance of Genome Resources

HGNC:4937

Annotation

Keyword

3D-structure
Disulfide bond
Endosome
Glycoprotein
Lysosome
MHC II
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P13765	MHC class II antigen DOB
Q5QNS2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
peptide antigen assembly with MHC class II protein complex	IBA
negative regulation of antigen processing and presentation of peptide antigen via MHC class II	IDA	22733780
antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA
positive regulation of immune response	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class II protein complex

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of antigen processing and presentation [inference]

negative regulation of antigen processing and presentation [inference]

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of antigen processing and presentation of peptide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

negative regulation of immune system process [inference]

negative regulation of antigen processing and presentation [inference]

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of immune response

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of immune response [inference]

positive regulation of immune response

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of immune response

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of antigen processing and presentation [inference]

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

negative regulation of antigen processing and presentation of peptide antigen [inference]

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

regulation of immune response [inference]

positive regulation of immune response

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of T cell activation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
lysosome	IDA	8890155
lysosomal membrane	TAS
lysosomal membrane	IBA
late endosome membrane	IBA
MHC class II protein complex	IDA	22733780

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class II protein complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
MHC class II protein complex binding	IDA	22733780
MHC class II protein complex binding	IBA
MHC class II receptor activity	TAS	2998758
peptide antigen binding	IBA

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

amide binding [inference]

peptide binding [inference]

peptide antigen binding

protein-containing complex binding [inference]

MHC protein complex binding [inference]

MHC class II protein complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

MHC class II receptor activity

immune receptor activity [inference]

MHC class II receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

HLA class II histocompatibility antigen, DO beta chain

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
immune response

Displaying **all 4** entries
InterPro
Immunoglobulin C1-set
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **21 - 30** of 95 in total

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Species	Gene ID	Orthologous MAtrix
Equus caballus	100060770	HORSE18522
Sus scrofa	100135049	PIGXX31279
Oryctolagus cuniculus	100351416	RABIT02300
Pongo abelii	100444404	PONAB31169
Nomascus leucogenys	100603684	NOMLE18040
Oreochromis niloticus	100628564	ORENI50483
Oreochromis niloticus	100690666	ORENI50483
Oreochromis niloticus	100699091	ORENI50930
Oreochromis niloticus	100701969	ORENI64389
Oreochromis niloticus	100701975	ORENI64464