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Fasciclin 2

Summary

Gene Symbol

Fas2

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

31364

PubChem

31364

Alliance of Genome Resources

FB:FBgn0000635

Annotation

Keyword

Alternative splicing
Cell adhesion
Cell membrane
Developmental protein
Differentiation
Disulfide bond
GPI-anchor
Immunoglobulin domain
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
P34082	Fasciclin II
M9PJ19
X2JAF4
M9PGF6
X2JCI0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 27 in total

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GO Term	Evidence Code	PMID
homophilic cell adhesion via plasma membrane adhesion molecules	IBA IDA	1913818
motor neuron axon guidance	IMP	24560702
photoreceptor cell axon guidance	IMP	15607949
axon guidance	IBA
imaginal disc-derived male genitalia morphogenesis	IMP	12702654

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

cell recognition [inference]

neuron recognition

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

neuron projection fasciculation [inference]

axonal fasciculation

cell junction organization [inference]

synapse organization

neuromuscular junction development

presynapse organization [inference]

terminal button organization

reproductive process [inference]

developmental process involved in reproduction [inference]

genitalia morphogenesis [inference]

post-embryonic genitalia morphogenesis [inference]

imaginal disc-derived genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

learning [inference]

associative learning [inference]

olfactory learning

memory [inference]

short-term memory

behavior [inference]

learning or memory

learning [inference]

associative learning [inference]

olfactory learning

memory [inference]

short-term memory

chemosensory behavior [inference]

olfactory behavior [inference]

olfactory learning

adult behavior [inference]

behavioral response to ethanol

developmental process [inference]

developmental process involved in reproduction [inference]

genitalia morphogenesis [inference]

post-embryonic genitalia morphogenesis [inference]

imaginal disc-derived genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

cell morphogenesis involved in neuron differentiation

animal organ morphogenesis [inference]

genitalia morphogenesis [inference]

post-embryonic genitalia morphogenesis [inference]

imaginal disc-derived genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

Bolwig's organ morphogenesis

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

anatomical structure development [inference]

mushroom body development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of circadian rhythm [inference]

regulation of locomotor rhythm

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of neuron differentiation [inference]

regulation of neuron maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of neuron remodeling [inference]

negative regulation of neuron remodeling

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of cell maturation [inference]

regulation of neuron maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of neuron remodeling [inference]

negative regulation of neuron remodeling

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of neuron differentiation [inference]

regulation of neuron maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of neuron remodeling [inference]

negative regulation of neuron remodeling

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of cell maturation [inference]

regulation of neuron maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of neuron remodeling [inference]

negative regulation of neuron remodeling

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of cell maturation [inference]

negative regulation of neuron maturation [inference]

negative regulation of neuron remodeling

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of neuromuscular junction development [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of locomotor rhythm

regulation of biological quality [inference]

regulation of tube architecture, open tracheal system [inference]

regulation of tube size, open tracheal system [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube size, open tracheal system [inference]

regulation of tube diameter [inference]

regulation of tube diameter, open tracheal system

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
membrane	IEA
postsynaptic membrane	IDA	18070911
type I terminal bouton	IDA	19379781
apical plasma membrane	IDA	15056617
plasma membrane	HDA IBA IDA	18394891 1913818 19317464

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

neuromuscular junction

site of polarized growth [inference]

growth cone

leading edge membrane

cell projection

plasma membrane bounded cell projection [inference]

neuron projection

axon

organelle [inference]

postsynaptic specialization [inference]

muscle cell postsynaptic specialization

presynapse [inference]

terminal bouton [inference]

type I terminal bouton

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15976083
cell-cell adhesion mediator activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

neural cell adhesion molecule 1-A

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Neural cell adhesion

Alliance of Genome Resources

Expression

Displaying entries **1 - 10** of 19 in total

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Location	References
apical plasma membrane	PMID:15056617
type II terminal bouton	PMID:14689489
muscle cell postsynaptic specialization	PMID:19850080
terminal bouton	PMID:14960613
type I terminal bouton	PMID:19379781
presynaptic periactive zone	PMID:18439405
neuromuscular junction	PMID:18070911 PMID:19379781 PMID:19850080 PMID:30904609
membrane	FB:FBrf0231198 PMID:15071179
leading edge membrane	PMID:15056617
growth cone	PMID:1913818

Disease

Disease Ontology

Displaying entries **1 - 10** of 23 in total

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DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0050933	ovarian serous carcinoma	Alliance of Genome Resources
DOID:0060318	acute promyelocytic leukemia	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11206	opioid abuse	Alliance of Genome Resources
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 51 in total

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Species	Gene ID	OrthoDB
Drosophila ficusphila	108091283	30025_0:001ac8
Drosophila eugracilis	108103528	29029_1:0010b8
Drosophila bipectinata	108119683	42026_0:000e1f
Drosophila elegans	108149913	30023_1:0006be
Drosophila miranda	108151943	7229_1:000d8c
Drosophila busckii	108606304	30019_1:002ab6
Drosophila arizonae	108618570	7263_1:002e75
Drosophila navojoa	108657097	7232_1:00256b
Drosophila serrata	110181705	7274_0:001b4f
Drosophila obscura	111076066	7282_0:0032c8

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements