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poly (ADP-ribose) polymerase family, member 16

Summary

Gene Symbol

Parp16

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

315760

PubChem

315760

Alliance of Genome Resources

RGD:1306243

Annotation

Keyword

ADP-ribosylation
Endoplasmic reticulum
Glycosyltransferase
NAD
Nucleotidyltransferase
Reference proteome
Transmembrane helix
Unfolded protein response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6J5E5
Q5U2Q4	ADP-ribosyltransferase diphtheria toxin-like 15 Poly [ADP-ribose] polymerase 16

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum unfolded protein response	IBA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein auto-ADP-ribosylation

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

IRE1-mediated unfolded protein response

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

negative regulation of cytoplasmic translation

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of cytoplasmic translation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nuclear envelope	IBA IEA ISO
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	IEA
membrane	IEA
endoplasmic reticulum tubular network	IBA IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle subcompartment [inference]

endoplasmic reticulum subcompartment [inference]

endoplasmic reticulum tubular network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
protein serine/threonine kinase activator activity	IBA IEA ISO
nucleotidyltransferase activity	IEA
NAD+- protein-lysine ADP-ribosyltransferase activity	IEA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

NAD+ ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity

catalytic activity, acting on a protein [inference]

NAD+-protein ADP-ribosyltransferase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein serine/threonine kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	36841	FB:FBgn0034129
Danio rerio	405842	ZFIN:ZDB-GENE-040426-2289
Xenopus tropicalis	100489635	Xenbase:XB-GENE-991444
Homo sapiens	54956	HGNC:26040
Mus musculus	214424	MGI:2446133

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Last updated: August 19, 2024