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heme oxygenase 2

Summary

Gene Symbol

HMOX2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3163

PubChem

3163

Alliance of Genome Resources

HGNC:5014

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Heme
Microsome
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
S-nitrosylation
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P30519
A0A087WT44
B3KSE0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
heme oxidation	IBA
heme catabolic process	IBA
response to hypoxia	IDA	15528406
response to oxidative stress	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heme metabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

pigment metabolic process [inference]

heme metabolic process [inference]

pigment catabolic process [inference]

heme catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heme metabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heme metabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heme metabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heme metabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heme metabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heme metabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

porphyrin-containing compound catabolic process [inference]

heme catabolic process

response to stimulus [inference]

response to stress [inference]

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
endoplasmic reticulum membrane	TAS
plasma membrane	IDA TAS	15528406
specific granule membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

specific granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

specific granule membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15528406 32296183 32814053
metal ion binding	IEA
heme binding	IBA
heme oxygenase (decyclizing) activity	IBA IDA	1575508 7890772

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

heme oxygenase (decyclizing) activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

heme oxygenase (decyclizing) activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heme oxygenase

Functional Category

H: Coenzyme transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
heme binding
heme catabolic process
heme oxidation
heme oxygenase (decyclizing) activity
response to oxidative stress

Displaying **all 3** entries
InterPro
Haem oxygenase-like, multi-helical
Haem oxygenase-like
Haem oxygenase

Ortholog

Displaying entries **1 - 10** of **109** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15369		MGI:109373	MOUSE18931
Drosophila melanogaster	41407		FB:FBgn0037933
Rattus norvegicus	79239		RGD:67402	RATNO00419
Sus scrofa	396622			PIGXX20995
Xenopus laevis	444101		Xenbase:XB-GENE-6255973
Pan troglodytes	453880	9598_0:0041e7		PANTR11643
Canis lupus familiaris	479864			CANLF16612
Bos taurus	510243			BOVIN20203
Macaca mulatta	705461			MACMU26376
Xenopus tropicalis	780096		Xenbase:XB-GENE-948111

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024