hepatocyte nuclear factor 4 alpha

Summary
Gene Symbol
  • HNF4A
Organism
Homo sapiens (human)
NCBI Gene
3172
PubChem
3172
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Activator
  • Alternative promoter usage
  • Alternative splicing
  • Biological rhythms
  • DNA-binding
  • Diabetes mellitus
  • Disease variant
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Repressor
  • Transcription regulation
  • Ubl conjugation
  • Zinc-finger
Proteins
Displaying all 5 entries
UniProt Protein Name
F1D8S2
F1D8T1
F1D8T0
P41235
  • Nuclear receptor subfamily 2 group A member 1
  • Transcription factor 14
  • Transcription factor HNF-4
B9VVT8
Gene Ontology (GO)
Displaying entries 31 - 32 of 32 in total
GO Term Evidence Code PMID
triglyceride homeostasis
regulation of ornithine metabolic process
GO Hierarchy
GO Hierarchy
OrthoDB (Group)
Group level
Eukaryota
Group Name
nuclear receptor subfamily 2, group F, member 2
Functional Category
  • E: Amino acid transport and metabolism
  • Q: Secondary metabolites biosynthesis, transport and catabolism
  • T: Signal transduction mechanisms
Disease
Disease Ontology
Displaying all 5 entries
DO ID Disease Name Source
DOID:0080760 Fanconi renotubular syndrome 4
DOID:0111099 maturity-onset diabetes of the young type 1
DOID:13809 familial combined hyperlipidemia
DOID:9352 type 2 diabetes mellitus
DOID:9993 hypoglycemia

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 8, 2025