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ubiquilin 2

Summary

Gene Symbol

Ubqln2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

317396

PubChem

317396

Alliance of Genome Resources

RGD:1563566

Annotation

Keyword

Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
D4AA63
A6KL57

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
autophagosome assembly	IBA
ubiquitin-dependent protein catabolic process	IBA
regulation of macroautophagy	ISO
regulation of macroautophagy	IBA
ERAD pathway	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of G protein-coupled receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

regulation of G protein-coupled receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of cellular process [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

positive regulation of response to stimulus [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of G protein-coupled receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

positive regulation of response to stimulus [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of G protein-coupled receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cellular component biogenesis [inference]

regulation of organelle assembly [inference]

regulation of autophagosome assembly

positive regulation of cellular process [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

regulation of G protein-coupled receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of organelle organization [inference]

regulation of vacuole organization [inference]

regulation of autophagosome assembly

regulation of organelle assembly [inference]

regulation of autophagosome assembly

negative regulation of cellular component organization [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

regulation of G protein-coupled receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor internalization [inference]

negative regulation of G protein-coupled receptor internalization

negative regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasm	ISO
cytosol	ISO
cytosol	IBA
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	27191843
polyubiquitin modification-dependent protein binding	IBA
identical protein binding	ISO
molecular condensate scaffold activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

modification-dependent protein binding [inference]

polyubiquitin modification-dependent protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

molecular condensate scaffold activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquilin

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
polyubiquitin modification-dependent protein binding

Displaying **all 6** entries
InterPro
Heat shock chaperonin-binding
UBA-like superfamily
Ubiquilin
Ubiquitin-associated domain
Ubiquitin-like domain superfamily
Ubiquitin-like domain

Ortholog

Displaying entries **1 - 10** of 43 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	29978	Xenbase:XB-GENE-986025	HUMAN100926
Xenopus tropicalis	29979	Xenbase:XB-GENE-986025
Saccharomyces cerevisiae S288C	50613	SGD:S000004889
Mus musculus	54609	Xenbase:XB-GENE-986025	MOUSE65197
Saccharomyces cerevisiae S288C	56893	SGD:S000004889
Saccharomyces cerevisiae S288C	94232	SGD:S000004889
Xenopus tropicalis	317396	Xenbase:XB-GENE-986025
Canis lupus familiaris	491909		CANLF19822
Macaca mulatta	707967		MACMU46885
Ciona intestinalis	100175472		CIOIN07619

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements