GlyCosmos Portal

Displaying **all 5** entries
GO Term	Evidence Code	PMID
acetyl-CoA carboxylase activity	IBA IDA ISS TAS	20457939 20952656 26976583 29899443
metal ion binding	IEA
ATP binding	IEA
protein binding	IPI	16326698 16794074 18056116 19343720 20457939 20952656 29899443
identical protein binding	IPI	20457939

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-carbon bonds [inference]

CoA carboxylase activity [inference]

acetyl-CoA carboxylase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000278540

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K11262

Name

acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]

References

Rhea

RHEA:11308

hydrogencarbonate + ATP + acetyl-CoA

H⁺ + phosphate + ADP + malonyl-CoA

Enzyme

6.4.1.2

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **261** in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050588	muscular dystrophy-dystroglycanopathy type B1	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET DisGeNET
DOID:0050771	pheochromocytoma	DisGeNET
DOID:0050773	paraganglioma	DisGeNET
DOID:0050782	Zollinger-Ellison syndrome	DisGeNET
DOID:0060041	autism spectrum disorder	DisGeNET
DOID:0060058	lymphoma	DisGeNET

The Human Phenotype Ontology

Displaying **all 6** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0001252	Hypotonia
HP:0001263	Global developmental delay
HP:0001510	Growth delay
HP:0002151	Increased circulating lactate concentration
HP:0003198	Myopathy

Displaying 1 entry
Disease ID	Disease Name
OMIM:613933	acetyl-coa carboxylase deficiency

PubChem Disease

MedGen Diseases

Acetyl-CoA: carboxylase deficiency

OMIM Phenotypes

ACETYL-CoA CARBOXYLASE-ALPHA DEFICIENCY; ACACAD

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006646
Gene Name: acetyl-CoA carboxylase alpha

Ortholog

Displaying entries **21 - 30** of 82 in total

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Species	Gene ID	Orthologous MAtrix
Ornithorhynchus anatinus	100078541	ORNAN08691
Callithrix jacchus	100397258	CALJA33183
Cercocebus atys	105583374	CERAT21209
Macaca fascicularis	102138812	MACFA13947
Macaca mulatta	714218	MACMU15557
Macaca nemestrina	105476887	MACNE29708
Papio anubis	101015557	PAPAN14157
Mandrillus leucophaeus	105546896	MANLE27800
Gorilla gorilla gorilla	101137945	GORGO35205
Pan paniscus	100985436	PANPA16899

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements