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haptoglobin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

3240

PubChem

3240

Alliance of Genome Resources

HGNC:5141

Annotation

Keyword

3D-structure
Acute phase
Alternative splicing
Antibiotic
Antioxidant
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hemoglobin-binding
Immunity
Proteomics identification
Reference proteome
Repeat
Secreted
Serine protease homolog
Signal
Sushi

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P00738	Zonulin
Q6PEJ8
A0A0C4DGL8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
proteolysis
negative regulation of hydrogen peroxide catabolic process	IDA	19740759
response to hydrogen peroxide	IDA	19740759
acute-phase response	IEA
negative regulation of oxidoreductase activity	IDA	19740759

GO Hierarchy

biological process

immune system process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

cellular process [inference]

cellular detoxification [inference]

cellular oxidant detoxification

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

defense response to other organism [inference]

defense response to bacterium

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to chemical [inference]

response to organic substance [inference]

response to hydrogen peroxide

response to inorganic substance [inference]

response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide catabolic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of oxidoreductase activity

regulation of oxidoreductase activity [inference]

negative regulation of oxidoreductase activity

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
blood microparticle	HDA	22516433
extracellular space	HDA IBA IDA	16502470 19433579 21805676 22664934 25645918
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

protein-containing complex [inference]

haptoglobin-hemoglobin complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19758344 31142615
hemoglobin binding	IDA	19740759
antioxidant activity	IEA
serine-type endopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

hemoglobin binding

antioxidant activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Trypsin

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Disease

Disease Ontology

Displaying entries **31 - 40** of 41 in total

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DO ID	Disease Name	Source
DOID:583	hemolytic anemia	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9477	pulmonary embolism	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15439		MGI:96211	MOUSE57964
Rattus norvegicus	24464		RGD:2825	RATNO14957
Bos taurus	280692			BOVIN10728
Sus scrofa	397061			PIGXX27148
Pan troglodytes	454233	9598_0:0042ca
Canis lupus familiaris	479668			CANLF15993
Danio rerio	566096		ZFIN:ZDB-GENE-030131-1259	DANRE41173
Macaca mulatta	706936			MACMU26470
Macaca mulatta	709274			MACMU26456
Pan troglodytes	745555	9598_0:004319