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hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Summary

Gene Symbol

HSD3B1

Aliases

SDR11E1
short chain dehydrogenase/reductase family 11E, member 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3283

HGNC

5217

KEGG Gene ID

hsa:3283

PubChem

3283

Alliance of Genome Resources

HGNC:5217

Annotation

Keyword

Direct protein sequencing
Endoplasmic reticulum
Isomerase
Mitochondrion
Multifunctional enzyme
NAD
NADP
Oxidoreductase
Reference proteome
Steroid metabolism
Steroidogenesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P14060	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I 3-beta-hydroxy-5-ene steroid dehydrogenase 3-beta-hydroxy-Delta(5)-steroid dehydrogenase 3-beta-hydroxysteroid 3-dehydrogenase Delta-5-3-ketosteroid isomerase Dihydrotestosterone oxidoreductase Steroid Delta-isomerase Trophoblast antigen FDO161G

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
hippocampus development	IBA
estrogen biosynthetic process		1944309
response to corticosterone	IBA
androgen biosynthetic process		1944309
steroid biosynthetic process	IBA ISS	1944309

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

cellular process [inference]

C21-steroid hormone metabolic process

developmental process [inference]

anatomical structure development [inference]

hippocampus development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

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GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IBA
endoplasmic reticulum	IDA
mitochondrial inner membrane	IDA	8274411
cytoplasm	IBA
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

smooth endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

bounding membrane of organelle [inference]

smooth endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

nucleolus

intercellular bridge

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GO Term	Evidence Code	PMID
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA
5alpha-androstane-3beta,17beta-diol dehydrogenase activity	IEA
3-beta-hydroxy-delta5-steroid dehydrogenase activity	ISS	1944309
protein binding	IPI	32296183 32814053
steroid delta-isomerase activity	ISS	1944309

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

3-keto sterol reductase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing C=C bonds [inference]

steroid delta-isomerase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000203857

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00070

Name

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]

References

2243100

Rhea

RHEA:32187

cholest-5-en-3-one

cholest-4-en-3-one

Enzyme

5.3.3.1

PMID

RHEA:18409

4α-methyl-5α-cholest-7-en-3β-ol + NADP⁺

H⁺ + 4α-methyl-5α-cholest-7-en-3-one + NADPH

Enzyme

1.1.1.270

PMID

RHEA:14709

a 3-oxo-Δ⁵-steroid

a 3-oxo-Δ⁴-steroid

Enzyme

5.3.3.1

PMID

RHEA:16297

5α-androstane-3β,17β-diol + NADP⁺

H⁺ + 17β-hydroxy-5α-androstan-3-one + NADPH

Enzyme

1.1.1.210

PMID

RHEA:24076

a 3β-hydroxy-Δ⁵-steroid + NAD⁺

H⁺ + a 3-oxo-Δ⁵-steroid + NADH

Enzyme

1.1.1.145

PMID

RHEA:43932

3β-hydroxyandrost-5-en-17-one + NAD⁺

H⁺ + NADH + androst-5-ene-3,17-dione

Enzyme

1.1.1.145

PMID

RHEA:34787

a 3β-hydroxysteroid + NADP⁺

H⁺ + a 3-oxosteroid + NADPH

Enzyme

1.1.1.270

PMID

RHEA:36379

3-dehydro-4α-methylzymosterol + H⁺ + NADPH

4α-methylzymosterol + NADP⁺

Enzyme

1.1.1.270

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050328	congenital hypothyroidism	DisGeNET
DOID:0050639	primary cutaneous amyloidosis	DisGeNET
DOID:0050811	congenital adrenal hyperplasia	DisGeNET DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET DisGeNET
DOID:10534	stomach cancer	DisGeNET DisGeNET
DOID:10591	pre-eclampsia	DisGeNET
DOID:10763	hypertension	DisGeNET DisGeNET Alliance of Genome Resources
DOID:10825	essential hypertension	DisGeNET DisGeNET
DOID:11054	urinary bladder cancer	DisGeNET DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001862
Gene Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39918	FB:FBgn0036698
Callorhinchus milii	103180179		CALMI19670
Latimeria chalumnae	102345588		LATCH10712
Danio rerio	373131	ZFIN:ZDB-GENE-030828-2	DANRE19159
Danio rerio	553532	ZFIN:ZDB-GENE-081105-30	DANRE44074
Astyanax mexicanus	103027852		ASTMX09819
Ictalurus punctatus	100304475		ICTPU30553
Electrophorus electricus	113587753		ELEEL39621
Salmo trutta	115161098		SALTR16062
Gadus morhua	115533088		GADMO29243

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements