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hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Summary

Gene Symbol

HSD3B1

Aliases

SDR11E1
short chain dehydrogenase/reductase family 11E, member 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3283

HGNC

5217

KEGG Gene ID

hsa:3283

PubChem

3283

Alliance of Genome Resources

HGNC:5217

Annotation

Keyword

Direct protein sequencing
Endoplasmic reticulum
Isomerase
Mitochondrion
Multifunctional enzyme
NAD
NADP
Oxidoreductase
Reference proteome
Steroid metabolism
Steroidogenesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P14060	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I 3-beta-hydroxy-5-ene steroid dehydrogenase 3-beta-hydroxy-Delta(5)-steroid dehydrogenase 3-beta-hydroxysteroid 3-dehydrogenase Delta-5-3-ketosteroid isomerase Dihydrotestosterone oxidoreductase Steroid Delta-isomerase Trophoblast antigen FDO161G

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
hippocampus development	IBA
estrogen biosynthetic process		1944309
response to corticosterone	IBA
androgen biosynthetic process		1944309
steroid biosynthetic process	IBA ISS	1944309

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

steroid hormone biosynthetic process [inference]

cellular process [inference]

C21-steroid hormone metabolic process

developmental process [inference]

anatomical structure development [inference]

hippocampus development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process

androgen metabolic process [inference]

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IBA
endoplasmic reticulum	IDA
mitochondrial inner membrane	IDA	8274411
cytoplasm	IBA
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

smooth endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

bounding membrane of organelle [inference]

smooth endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

nucleolus

intercellular bridge

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA
5alpha-androstane-3beta,17beta-diol dehydrogenase activity	IEA
3-beta-hydroxy-delta5-steroid dehydrogenase activity	ISS	1944309
protein binding	IPI	32296183 32814053
steroid delta-isomerase activity	ISS	1944309