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hydroxysteroid 17-beta dehydrogenase 1

Summary

Gene Symbol

HSD17B1

Aliases

Estradiol 17-beta-dehydrogenase-1
HSD17
MGC138140
SDR28C1
short chain dehydrogenase/reductase family 28CE, member 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3292

HGNC

5210

KEGG Gene ID

hsa:3292

PubChem

3292

Alliance of Genome Resources

HGNC:5210

Annotation

Keyword

3D-structure
Cytoplasm
Direct protein sequencing
NADP
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Steroid biosynthesis

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0A0MQS7
P14061	20 alpha-hydroxysteroid dehydrogenase E2DH Estradiol 17-beta-dehydrogenase 1 Placental 17-beta-hydroxysteroid dehydrogenase Short chain dehydrogenase/reductase family 28C member 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
estrogen biosynthetic process	IBA IDA IEA ISS	8994190
adipose tissue development	IEA
cellular response to metal ion	IEA
bone development	IEA
testosterone biosynthetic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

estrogen biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

macromolecule biosynthetic process [inference]

gene expression

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

hormone metabolic process [inference]

estrogen metabolic process

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

ketone biosynthetic process [inference]

testosterone biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

estrogen metabolic process

estrogen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

small molecule metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

estrogen metabolic process

estrogen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

olefinic compound metabolic process [inference]

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

estrogen metabolic process

estrogen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

macromolecule biosynthetic process [inference]

gene expression

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

organic hydroxy compound metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

skeletal muscle tissue development

connective tissue development [inference]

adipose tissue development

animal organ development [inference]

bone development

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

cellular response to metal ion

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

estrogen metabolic process

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IBA IDA TAS
cytoplasm		8547176

GO Hierarchy

cellular component

cellular anatomical entity [inference]

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GO Term	Evidence Code	PMID
catalytic activity		8547176
steroid binding	IDA	4396689
testosterone 17-beta-dehydrogenase (NADP+) activity	IEA
NADP+ binding	IMP	9525918
small molecule binding	EXP	9525918

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)] activity

testosterone dehydrogenase [NAD(P)] activity

testosterone dehydrogenase (NAD+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)] activity

testosterone dehydrogenase [NAD(P)] activity

testosterone dehydrogenase (NAD+) activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

steroid binding

estradiol binding

small molecule binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

NADP+ binding

ion binding [inference]

anion binding [inference]

NADP+ binding

organic cyclic compound binding [inference]

steroid binding

estradiol binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

NADP+ binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000108786

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00044

Name

17beta-estradiol 17-dehydrogenase [EC:1.1.1.62]

References

Rhea

RHEA:24616

17β-estradiol + NADP⁺

H⁺ + estrone + NADPH

Enzyme

1.1.1.62

PMID

RHEA:24612

17β-estradiol + NAD⁺

H⁺ + estrone + NADH

Enzyme

1.1.1.62

PMID

RHEA:14981

testosterone + NADP⁺

H⁺ + androst-4-ene-3,17-dione + NADPH

Enzyme

PMID

RHEA:14929

testosterone + NAD⁺

H⁺ + androst-4-ene-3,17-dione + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 82 in total

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DO ID	Disease Name	Source
DOID:0050811	congenital adrenal hyperplasia	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET
DOID:0110041	Alzheimer's disease 8	DisGeNET
DOID:0110043	Alzheimer's disease 10	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001096
Gene Name: hydroxysteroid (17-beta) dehydrogenase 1

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	402842	ZFIN:ZDB-GENE-040901-5	DANRE31675
Astyanax mexicanus	103039740		ASTMX17247
Ictalurus punctatus	108275553		ICTPU24612
Electrophorus electricus	113589863		ELEEL43562
Salmo salar	106601030		SALSA113685
Salmo salar	106607392		SALSA128592
Salmo trutta	115170610		SALTR91766
Salmo trutta	115203489		SALTR26529
Gadus morhua	115533726		GADMO39804
Oryzias latipes	100125484		ORYLA16474

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements