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transmembrane protein 67

Summary

Gene Symbol

Tmem67

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

329795

PubChem

329795

Alliance of Genome Resources

MGI:1923928

Annotation

Keyword

Alternative splicing
Cell membrane
Cilium
Cilium biogenesis/degradation
Cytoskeleton
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8BR76	Meckel syndrome type 3 protein homolog Transmembrane protein 67
A2AJP5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
kidney development	IMP	27002738
determination of left/right symmetry	IMP	25807483
heart development	IMP	25807483
negative regulation of centrosome duplication	ISO
negative regulation of centrosome duplication	IMP	19515853

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

photoreceptor cell outer segment organization

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

epithelial tube branching involved in lung morphogenesis

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

epithelial tube branching involved in lung morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube

epithelial tube branching involved in lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

epithelial tube branching involved in lung morphogenesis

anatomical structure development [inference]

animal organ development [inference]

head development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

positive regulation of response to stimulus [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway

regulation of microtubule-based process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of organelle assembly [inference]

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IDA	19815549
centrosome	ISO
cytoskeleton	IEA
plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

MKS complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

axoneme

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

ciliary transition zone

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying **all 3** entries
GO Term	Evidence Code	PMID
filamin binding	ISO
unfolded protein binding	ISO
misfolded protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

filamin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Meckelin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Meckelin

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:0050778	Meckel syndrome	Alliance of Genome Resources
DOID:0111001	Joubert syndrome 6	Alliance of Genome Resources
DOID:2975	cystic kidney disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements