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heparan sulfate proteoglycan 2
Summary
- Gene Symbol
-
- HSPG2
- Aliases
-
- PRCAN
- endorepellin
- perlecan
- perlecan proteoglycan
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Angiogenesis
- Basement membrane
- Calcium
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Heparan sulfate
- Immunoglobulin domain
- Laminin EGF-like domain
- Metal-binding
- Reference proteome
- Repeat
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P98160 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| animal organ regeneration | ||
| brain development |
|
|
| response to xenobiotic stimulus | ||
| angiogenesis | ||
| positive regulation of endothelial cell proliferation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| Golgi lumen |
|
|
| basement membrane |
|
|
| plasma membrane |
|
|
| focal adhesion |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| low-density lipoprotein particle receptor binding |
|
|
| amyloid-beta binding | ||
| extracellular matrix structural constituent conferring compression resistance | ||
| calcium ion binding | ||
| protein binding |
GO Hierarchy
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13810 | familial hypercholesterolemia | |
| DOID:1386 | abetalipoproteinemia | |
| DOID:1387 | hypolipoproteinemia | |
| DOID:1388 | Tangier disease | |
| DOID:13884 | sick sinus syndrome | |
| DOID:1391 | Norum disease | |
| DOID:13994 | cleidocranial dysplasia | |
| DOID:14018 | alcoholic liver cirrhosis | |
| DOID:14115 | toxic shock syndrome | |
| DOID:14221 | abdominal obesity-metabolic syndrome 1 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001548 | Overgrowth |
| HP:0001557 | Prenatal movement abnormality |
| HP:0001561 | Polyhydramnios |
| HP:0001601 | Laryngomalacia |
| HP:0001618 | Dysphonia |
| HP:0001620 | High pitched voice |
| HP:0001621 | Weak voice |
| HP:0001627 | Abnormal heart morphology |
| HP:0001636 | Tetralogy of Fallot |
| HP:0001643 | Patent ductus arteriosus |
| Disease ID | Disease Name |
|---|---|
| ORPHA:1606 |
|
| ORPHA:800 |
|
| ORPHA:1865 |
|
| OMIM:255800 |
|
| OMIM:224410 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 175126 | WB:WBGene00006787 | ||
| 45320 | FB:FBgn0284408 | ||
| 565429 | ZFIN:ZDB-GENE-080807-4 | DANRE24960 | |
| 100380784 | SALSA43220 | ||
| 115165633 | SALTR88020 | ||
| 103467813 | POERE30093 | ||
| 102290874 | HAPBU05628 | ||
| 113013483 | ASTCA20652 | ||
| 108696836 | Xenbase:XB-GENE-17341349 | ||
| 100494785 | Xenbase:XB-GENE-6465357 |
