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amyloid beta precursor like protein 1

Summary

Gene Symbol

APLP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

333

PubChem

333

Alliance of Genome Resources

HGNC:597

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Cell adhesion
Cell membrane
Copper
Cytoplasm
Disulfide bond
Endocytosis
Glycoprotein
Heparin-binding
Metal-binding
Neurodegeneration
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P51693	Amyloid beta (A4) precursor-like protein 1 Amyloid-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
cellular response to norepinephrine stimulus	IDA	16531006
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	16531006
cytoplasmic polyadenylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

cellular process [inference]

cell adhesion

cell death [inference]

programmed cell death [inference]

apoptotic process

vesicle-mediated transport [inference]

endocytosis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

RNA 3'-end processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing [inference]

cytoplasmic polyadenylation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

forebrain development

system development [inference]

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

response to organic cyclic compound [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to oxygen-containing compound [inference]

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

response to norepinephrine [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to norepinephrine stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
basement membrane	TAS	9521588
nucleoplasm	IDA
Golgi apparatus	IDA
Golgi apparatus	IBA
plasma membrane	IDA	16531006

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16169070 16193067 21293490 32814053
heparin binding	IEA
alpha-2A adrenergic receptor binding	IBA
alpha-2A adrenergic receptor binding	IPI	16531006
alpha-2B adrenergic receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

adrenergic receptor binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

amyloid beta precursor protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
central nervous system development
heparin binding
metal ion binding
serine-type endopeptidase inhibitor activity
transition metal ion binding

Displaying entries **1 - 10** of 15 in total

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InterPro
Amyloidogenic glycoprotein, E2 domain
Amyloidogenic glycoprotein, copper-binding domain conserved site
Amyloidogenic glycoprotein, copper-binding domain superfamily
Amyloidogenic glycoprotein, copper-binding
Amyloidogenic glycoprotein, extracellular
Amyloidogenic glycoprotein, heparin-binding domain superfamily
Amyloidogenic glycoprotein, heparin-binding
Amyloidogenic glycoprotein, intracellular domain, conserved site
Amyloidogenic glycoprotein
Beta-amyloid precursor protein C-terminal

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	333	Xenbase:XB-GENE-853203
Drosophila melanogaster	334	FB:FBgn0000108
Drosophila melanogaster	351	FB:FBgn0000108
Mus musculus	11803	Xenbase:XB-GENE-853203	MOUSE54988
Drosophila melanogaster	11804	FB:FBgn0000108
Drosophila melanogaster	11820	FB:FBgn0000108
Xenopus tropicalis	31002	Xenbase:XB-GENE-853203
Drosophila melanogaster	54226	FB:FBgn0000108
Xenopus tropicalis	180783	Xenbase:XB-GENE-853203
Danio rerio	404233		DANRE09497

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OrthoDB (Group)

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Acknowledgements