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5-hydroxytryptamine receptor 1F

Summary

Gene Symbol

HTR1F

Organism

Homo sapiens (human)

External Links

NCBI Gene

3355

PubChem

3355

Alliance of Genome Resources

HGNC:5292

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P30939	Serotonin receptor 1F

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	21422162
adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA	34239069 35610220 35835867
adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA
chemical synaptic transmission	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IMP	21422162
plasma membrane	IBA
dendrite	IBA
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
Gi/o-coupled serotonin receptor activity	IDA	34239069
G protein-coupled serotonin receptor activity	IDA	8380639
G protein-coupled serotonin receptor activity	IMP	21422162
G protein-coupled serotonin receptor activity	IBA
neurotransmitter receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gi/o-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-hydroxytryptamine receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
G protein-coupled serotonin receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
chemical synaptic transmission

Displaying **all 3** entries
InterPro
5-hydroxytryptamine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **1 - 10** of 98 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	3350	WB:WBGene00004779
Caenorhabditis elegans	3351	WB:WBGene00004779
Caenorhabditis elegans	3352	WB:WBGene00004779
Caenorhabditis elegans	3354	WB:WBGene00004779
Xenopus tropicalis	3355	Xenbase:XB-GENE-1010473
Caenorhabditis elegans	15550	WB:WBGene00004779
Caenorhabditis elegans	15551	WB:WBGene00004779
Caenorhabditis elegans	15552	WB:WBGene00004779
Mus musculus	15557	Xenbase:XB-GENE-1010473	MOUSE18472
Caenorhabditis elegans	24473	WB:WBGene00004779